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| MRI, ASL and 1H-MRS features of MELAS syndrome |
| WU Ke, LI Rui, MA Lin, LI Ying, WANG Yan, WANG Yu-lin, LOU Xin |
| Department of Radiology, PLA General Hospital, Beijing 100853, China |
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Abstract Objective: To discuss diagnosis value of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes(MELAS) syndrome by MRI routine scan, ASL and 1H-MRS. Methods: A total of 9 patients with MELAS syndrome(6 males, 3 females, age 7～35 years old) were selected. MR routine and enhanced scan, ASL perfusion imaging and 1H-MRS were performed. Results: In 9 cases, 2 cases of bilateral disease, 7 cases of unilateral disease. One case involved the cerebellar hemisphere. MRI routine scan(parietal lobe, occipital lobe, temporal lobe) cortex were swelling, cortical and subcortical white matter was slightly lower signal on T1WI, brain-like high signal was showed on T1WI of 1 case cortex, T2WI was slightly higher signal. FLAIR showed high signal, DWI showed high signal, and ADC map showed hypointensity. Brain-like enhanced was showed on post contrast images of cerebral cortex. Lesions were significantly higher perfusion on ASL. 1H-MRS: when TE was 35 ms, the NAA peak decreased, Cho peaks raised slightly, and Lac bimodal was showed, when TE was 144 ms, inverted Lac bimodal was observed. Conclusion: MRI routine scan and ASL, 1H-MRS is characterized, MRI and ASL and 1H-MRS is important for diagnose and differential diagnose.
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Received: 17 April 2017
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