S-Detect技术应用于超声诊断乳腺包块的影响因素及与超声医师联合诊断的分析

doi:10.12117/jccmi.2020.01.006

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Abstract Objective: To investigate the influence factors of the sensitivity, specificity and accuracy of S-Detect. To analyze the diagnostic value and the agreement of the combined diagnosis with a radiologist specializing in breast lesions. Methods: Grouped by the influence factors of S-Detect, chi-square test was used to calculate and compare the sensitivity, specificity and accuracy of S-Detect. Logistic regression was used to analyze the relationship between various factors and the results of pathological diagnosis that was benign or malignant. Breast ultrasound and S-Detect were operated by a radiologist specializing in breast imaging. The other radiologist analyzed the ultrasonographic images of the breast masses according to the American College of Radiology Breast Imaging Reporting and Data System(BI-RADS), and then made the combined diagnosis on the results of S-Detect. The area under the receiver operating characteristic(ROC) curve and the agreement among the S-Detect, radiologist, combined diagnosis were calculated and compared. Results: In all the 581 lesions, pathological diagnosis showed 411 benign lesions and 170 malignant lesions. The false positive rate of S-Detect in intraductal papilloma and which was between 2 cm to 4 cm was higher(P<0.05). The specificity of S-Detect was all higher than 80.00%. The sensitivity and specificity of S-Detect were not statistically significant in the groups of the age, the location of the lesions and the depth of the lesion. Three significant risk factors(age, S-Detect, the most largest size of lesions) for pathology were analyzed with logistic regression(P<0.05). Moderate agreement was seen in final assessments made by S-Detect, radiologist and combined diagnosis(the primary combined diagnosis)(Kappa=0.45, 0.571 and 0.65, respectively) with pathological results as the gold standard. Good agreement was seen in final assessments made by combined diagnosis in consideration of age and the largest size of lesions(the recombined diagnosis)(Kappa=0.76). The area under ROC curve was 0.78, 0.78, 0.84 and 0.89, respectively. Conclusion: The specificity of S-Detect was higher. The accuracy of S-Detect in intraductal papilloma was lower and the false negative rate of S-Detect in benign tumor of lesions between 2 cm to 4 cm was higher. S-Detect is a clinically feasible diagnostic tool that can be used to improve the diagnostic value and the agreement of the radiologist and pathological diagnosis.

Key words： Breast neoplasms Ultrasonography, Doppler, color

Received: 11 March 2019

PACS:	Ｒ737.9
	Ｒ445.1

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	Articles by authors
	YAN Hong
	LI Xiang
	CHENG Hui-fang
	WANG Xue-mei
	ZHANG Yi-xia
	KANG Shu

Cite this article:

YAN Hong,LI Xiang,CHENG Hui-fang, et al. Clinical application of S-Detect on breast masses on ultrasonography: a study analyzing the influence factors and #br# the combined diagnosis with a radiologist specializing in breast lesions[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(1): 24-29.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.01.006 OR http://www.jccmi.com.cn/EN/Y2020/V31/I1/24

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