超声引导下小剂量凝血酶注射治疗股动脉假性动脉瘤疗效分析

doi:10.12117/jccmi.2020.08.007

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Abstract Objective: To assess the efficacy and safety of ultrasound-guided thrombin injection(UGTI) in the treatment of femoral artery pseudoaneurysm(PSA). Method: From November 2017 to December 2019, 24 PSA patients confirmed by angiography or color Doppler ultrasound in our hospital were analyzed, including 19 cases of simple type and 5 cases of complex type. Under the guidance of color Doppler ultrasound, 20G PTC needle was used to puncture into the PSA cavity from the bottom of the PSA cavity far away from the PSA neck, and thrombin solution was injected slowly (concentration 250 IU/mL, total dose ≤1 000 IU). The near PSA cavity was injected preferentially for complex PSA. After operation, thrombin dosage and adverse reactions of each patient were recorded. Ultrasound(US) reexaminations were performed 24 hours and 1 week after operation, to observe the blood flow in PSA cavity and parent artery. Result: Blood flow signal in all 24 cases disappeared, only 2 patients(1 simple type, 1 complex type) had a little residual blood flow in the neck of the PSA. After 24 hours of compression, the blood flow in the neck of the simple PSA disappeared, and the complex PSA was treated successfully for the second time. The success rate of the first treatment was 95.8%(23/24), and the total success rate was 100.0%(24/24). The average thrombin dosage was (180±107) IU(25~500 IU). One patient had transient vasovagal syncope during the operation. One patient developed shivering, fever(39 ℃) 40 minutes after operation, with extensive skin rash, lower limb plaque and hypotension. After intravenous fluid infusion and intravenous injection of 5 mg dexamethasone, the patient was gradually and completely relieved. No adverse reactions and no recurrence were found in the other patients. Conclusion: Ultrasound-guided percutaneous low-dose thrombin injection is a safe and effective therapy method for treating PSA．

Key words： Aneurysm, false Thrombin Ultrasonography, interventional

Received: 26 April 2020

PACS:	Ｒ732.21
	Ｒ445.1

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	Articles by authors
	LIANG Xiao-qiu
	CAO Ling-ling
	CHEN Yi-xu
	WANG Yan
	DU Hao

Cite this article:

LIANG Xiao-qiu,CAO Ling-ling,CHEN Yi-xu, et al. The efficacy of ultrasound-guided low-dose thrombin injection in the management of femoral artery pseudoaneurysm[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 555-557.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.08.007 OR http://www.jccmi.com.cn/EN/Y2020/V31/I8/555

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