CT四维电磁导航引导125I放射性粒子植入治疗肺门旁非小细胞肺癌的应用研究

doi:10.12117/jccmi.2020.08.006

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Abstract Objective: To evaluate the clinical application values of CT electromagnetic navigation system-guided 125I seed implantation therapy for parahilar non-small cell lung carcinoma(NSCLC). Methods: A total of 26 patients with parahilar NSCLC treated by CT-guided 125I seed implantation therapy were retrospectively analyzed. The 125I seed implantation procedures were performed under CT electromagnetic navigation and routine CT guidance in 16 and 10 cases, respectively. The preoperative planning designs, intraoperative optimization and postoperative dosimetry verifications were performed for all patients. The dose related parameters including D90, MPD, V100, V150 and V200 were compared between pre- and post-operation by t test. The operating time, adjustment times of puncture needle, total radiation dose during the puncture and complications were also compared between the two groups. Results: All 26 patients were treated successfully without serious procedure-related complications. An average of 33 seeds were implanted in the CT electromagnetic navigation system-guided group, and 40 seeds were implanted in the routine CT guided group. Preoperative V100 in CT electromagnetic navigation system-guided group and routine CT guided group were (95.45±1.52)% and (93.47±2.37)%, respectively. Postoperative V100 in both groups were (89.83±2.78)% and (87.85±4.35)%, respectively. There was no significant difference between pre- and post-operation for all parametersexcept for V100. The operating time was (53.3±11.4) min in CT electromagnetic navigation system-guided group and (66.0±12.7) min in routine CT guided group. The adjustment times of puncture needle were (0.5±0.13) and (2.08±0.11) in both group, respectively. Total radiation dose during the puncture was (206.4±11.19) mGycm and (299.9±8.402) mGycm in both group, respectively. Compared with routine CT guided group, the mean value of the operating time, adjustment times of puncture needle and total radiation dose during the puncture decreased in CT electromagnetic navigation system-guided group. The differences between two groups were statistically significant(P＜0.01). Conclusions: Compared with the routine CT guidance, CT electromagnetic navigation system-guided 125I seed implantation therapy for NSCLC can achieve preoperative plans accurately, and effectively reduce the adjustment times of puncture needle, shorten the operation time, reduce radiation dose and improve the patients’ tolerance.

Key words： Carcinoma, non-small-cell lung Iodine Radiology, interventional

Received: 08 June 2020

PACS:	Ｒ734.2
	Ｒ814.42
	Ｒ815

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	Articles by authors
	CHEN Zhi-jin
	GONG Ju
	XIA Ning
	LU Jian
	WANG Zhong-min

Cite this article:

CHEN Zhi-jin,GONG Ju,XIA Ning, et al. Application research of CT electromagnetic navigation system-guided 125I seed implantation therapy in parahilar non-small cell lung carcinoma[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 551-554.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.08.006 OR http://www.jccmi.com.cn/EN/Y2020/V31/I8/551

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