头颅MRI T1WI信号强度比值在足月新生儿高胆红素血症中的应用

doi:10.12117/jccmi.2020.08.008

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Abstract Objective: To investigate the correlation between the signal intensity in globus pallidus(SIgp), the ratio of T1WI signal intensity in globus pallidus to putamen(G/P) and the grades of neonatal hyperbilirubinemia(NHB) and the value in diagnosing NHB brain injury. Methods: The clinical and MRI data of 224 cases of NHB hospitalized from January 2017 to November 2019 were collected, and divided into 6 groups according to the peak level of serum total bilirubin, ranging from B0 to B5. The SIgp and SIp were measured respectively, and the G/P ratio was calculated. The differences between SIgp and G/P in different groups were analyzed by One-way ANOVA. The correlation between SIgp, G/P and serum bilirubin level were analyzed by Spearman. The efficacy of SIgp and G/P in the diagnosis of bilirubin brain injury were analyzed by ROC. Results: There were significant differences in SIgp and G/P between different NHB grades(P<0.05). The differences of SIgp between B0 and B2, B3, B4, B5 groups, B1 and B4, B5 groups were statistically significant respectively(P<0.05). The differences of G/P between B0 and B2, B3, B4, B5 groups, B1 and B2, B3, B4, B5 groups, B2 and B3, B4, B5 groups, B3 and B5 groups, B4 and B5 groups were statistically significant respectively(P<0.01). There was a weak positive correlation between SIgp and NHB grades(rs=0.281, P<0.001), and a strong positive correlation between G/P and NHB grades(rs=0.714, P<0.001). The AUC of G/P in each group was significantly higher than that of SIgp, and the difference of ROC in each group was statistically significant(Z>1.96, P<0.05). Conclusion: G/P ratio can provide objective imaging evidence for the grades of NHB brain injury, and it’s diagnostic efficiency is better than SIgp. It is necessary to be alert to the occurrence of acute bilirubin encephalopathy(ABE) when the G/P ratio is ≥1.160.

Key words： Hyperbilirubinemia Infant, newborn Magnetic resonance imaging

Received: 06 January 2020

PACS:	Ｒ722.17
	Ｒ445.2

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	Articles by authors
	LAI Wei1
	XU Feng-dan1
	LIANG Run-qiu1
	FAN Miao2
	LI Qian-yi1
	LIU Li-zhen1
	LI Deng-hui1
	LI Ning1
	LIU Jian-xin1

Cite this article:

LAI Wei1,XU Feng-dan1,LIANG Run-qiu1, et al. The application of T1WI signal intensity ratio of cranial MRI in term neonatal hyperbilirubinemia[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 558-562.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.08.008 OR http://www.jccmi.com.cn/EN/Y2020/V31/I8/558

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