超声造影定量参数对肺部良恶性病变鉴别诊断的研究

doi:10.12117/jccmi.2020.01.008

Abstract
Figure/Table
References (14)
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To evaluate the value of quantitative parameters of contrast-enhanced ultrasonography in differential diagnosis of benign and malignant lung lesions. Methods: Fifty-one cases of lung lesions diagnosed by puncture pathology were divided into benign group and malignant group, the quantitative parameters of contrast-enhanced ultrasonography time intensity curve(TIC) and the time difference of contrast agent to lung lesions and adjacent lung tissues were quantitatively analyzed. Results: ①In the quantitative parameters of TIC, the contrast agent arrive time(AT) in the benign group was less than that in the malignant group, and the difference was statistically significant between the two groups(P<0.05). There was no significant difference in the time to peak(TTP), the rise time(RT), the maximum intensity(IMAX) and the rising slope(RS) between the two groups(P>0.05). ②Squamous cell carcinoma group and adenocarcinoma group were divided from malignant group. There was no significant difference in quantitative parameters of TIC between the two groups(P>0.05). ③The time difference of contrast agent to lung lesions and adjacent lung tissues in the benign group was less than that in the malignant group, and the difference was statistically significant between the two groups(P<0.05). The optimal cut-off point of the time difference was 2.5 s. Conclusion: ①The quantitative parameters of TIC have definite clinical value in the differential diagnosis of benign and malignant lung lesions. ②The time difference of contrast agent to lung lesions and adjacent lung tissues has certain value in the differential diagnosis of benign and malignant lung lesions. The time difference<2.5 s indicates that the lesions tend to be benign, and the time difference>2.5 s indicates that the lesions tend to be malignant.

Key words： Lung diseases Diagnosis, differential Ultrasonography, Doppler, color

Received: 01 February 2019

PACS:	Ｒ563
	Ｒ734.2
	Ｒ445.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHU Li-jing
	WANG Xing-hua

Cite this article:

ZHU Li-jing,WANG Xing-hua. Study on differential diagnosis of benign and malignant lung lesions with quantitative parameters of#br# contrast-enhanced ultrasonography[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(1): 34-37.

URL:

http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.01.008 OR http://www.jccmi.com.cn/EN/Y2020/V31/I1/34

[1]Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer, 2015, 136(5): E359-E386.
[2]张仁锋，张岩，温丰标，等. 6 058例肺癌患者病理类型和临床流行病学特征的分析[J]. 中国肺癌杂志，2016，19（3）：129-135.
[3]王慧，黄礼年. 支气管镜介入技术在外周肺病变中的应用[J]. 中国肺癌杂志，2016，19（8）：559-564.
[4]Volpicelli G. Lung sonography[J]. J Ultrasound Med, 2013, 32(1): 165-171.
[5]Sperandeo M, Rotondo A, Guglielmi G, et al. Transthoracic ultrasound in the assessment of pleural and pulmonary diseases: use and limitations[J]. Radiol Med, 2014, 119(10): 729-740.
[6]Perera RH, Hernandez C, Zhou H, et al. Ultrasound imaging beyond the vasculature with new generation contrast agents[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2015, 7(4): 593-608.
[7]Gorg C, Seifart U, Gorg K, et al. Color Doppler sonographic mapping of pulmonary lesions: evidence of dual arterial supply by spectral analysis[J]. J Ultrasound Med, 2003, 22(10): 1033-1039.
[8]刘慧，林江，陆秀良，等. 320排容积CT双血供灌注评估肺占位性病变的良恶性及与微血管密度的相关性[J]. 复旦学报：医学版，2016，43（3）：318-323.
[9]肖湘生，董生，董伟华，等. 肺癌血供系列研究[J]. 介入放射学杂志，2008，17（3）：169-171.
[10]Yuan A, Yu CJ, Kuo SH, et al. Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer[J]. J Clin Oncol, 2001, 19(2): 432-441.
[11]Wu JL, Li GJ, E YJ, et al. Diagnosis of peripheral lung cancer using MSCT perfusion imaging compared with microvessel density(MVD)[J]. Oncol Transl Med, 2006, 5(5): 312-315.
[12]Piscaglia F, Nolsoe C, Dietrich CF, et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound(CEUS): update 2011 on non-hepatic applications[J]. Ultraschall Med, 2012, 33(1): 33-59.
[13]苗立云，代静泓，桂贤华，等. 急性纤维蛋白性机化性肺炎的临床病理特征[J]. 临床肺科杂志，2010，15（9）：1260-1262.
[14]王学文，唐玉梅，宋萍. 淀粉样变与出血：病理生理学、诊断和治疗[J]. 现代肿瘤医学，2009，17（9）：1810-1814.