Abstract Objective: To explore the value of ultrasound elastography in determining the degree of chronic nephropathy in children. Methods: Based on the pathological results of renal puncture biopsy, 40 patients with chronic kidney disease(CKD) and 40 normal control cases were collected. Both the ratio of male to female was 1∶1. Firstly, two-dimensional ultrasound images were collected to record the location, size, shape, echo, boundary and blood flow signal distribution of the Kidney. After the image was stabilized, the elastic imaging mode was activated, and real-time elastic imaging was performed on the right lower pole of the kidney. Young’s modulus value of the renal cortex was measured repeatedly within 5~7 cm depth and the region of interest(ROI) diameter within 5~7 mm, and the difference was compared after quantitative analysis. Results: The Young’s modulus value of renal cortex in CKD patients who were diagnosed by biopsy was (6.72±1.93) kPa, compared with the value of (3.19±0.62) kPa in control group. The difference was statistically significant(P<0.05). It indicates that the hardness of the kidney of the sick child is greater than the healthy child. Conclusion: Real-time shear wave ultrasound elastography can quantitatively detect the Young’s modulus of renal cortex in children patients with CKD and healthy children, and it is concluded that the Young’s modulus of renal cortex in children with CKD is larger than healthy children. Shear wave ultrasound elastography can help clinicians in the diagnosis and treatment of children with CKD.
GAO Feng,JIANG Su-qi. Study on the application value of shear wave ultrasound elastography in the diagnosis of chronic nephropathy in children[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(8): 574-577.
[1]吴进仕，宋嫦娥，艾军. 慢性肾病湿热致瘀的病理机制及治疗探讨[J]. 浙江中医杂志，2006，41（4）：187-189.
[2]Goloveshkin YV, Tuzlukova NI. Role of the normal elasticity modulus as a connecting criterion in selecting structural materials[J]. Strength Mater, 1988, 20(2): 176-180.
[3]Ophir J, Caspedes I, Ponnekanti H, et al. Elastography: a quantitative for imaging the elasticity of biological tissues[J]. Ultrason Imaging, 1991, 13(2): 111-134.
[4]National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification[J]. Am J Kidney Dis, 2002, 39(2 suppl 1): S1-S266.
[5]黄品同，王力孔，凡雷，等. 声辐射力脉冲成像技术对兔急性淤血肝的弹性评价[J]. 肝胆胰外科杂志，2009，21（3）：184-186.
[6]Thomas A, Fischer T, Frey H, et al. Real-time elastography—an advanced method of ultrasound: First results in 108 patients with breast lesions[J]. Ultrasound Obstet Gynecol, 2006, 28(3): 335-340.
[7]Garra BS, Cespedes EI, Ophir J, et al. Elastography of breast lesions: initial clinical results[J]. Radiology, 1997, 202(1): 79-86.
[8]Cochlin DL, Ganatra RH, Griffiths DF. Elastography in the detection of prostatic cancer[J]. Clin Radiol, 2002, 57(22): 1014-1020.
[9]Miyanaga N, Akaza H, Yamakawa M, et al. Tissue elasticity imaging for diagnosis of prostate cancer: a preliminary report[J]. Int J Urol, 2006, 13(12): 1514-1518.
[10]姚春晓，傅宁华，杨斌，等. 声触诊组织定量分析在慢性肾病中应用的初步探讨[J]. 中国超声医学杂志，2009，25（12）：1169-1172.
[11]徐建红，刘智惠，靳霞，等. 剪切波定量超声弹性成像技术在慢性肾病中应用的初步研究[J]. 中华医学超声杂志：电子版，2012，9（5）：405-407.
[12]王海燕. 肾脏病学[M]. 3版. 北京：人民出版社，2009：799-820.
