Abstract Objective: To investigate the effect of 3.0T magnetic resonance elastography(MRE) on the evaluation of non-alcoholic fatty liver disease(NAFLD) patients and prediction the liver fibrosis. Methods: The preoperative liver stiffness of 20 healthy volunteers(normal group) and 57 patients(pathological group) diagnosed with NAFLD by liver biopsy were analyzed by 3.0T MRE. Receiver operating characteristic curve(ROC) was used to evaluate the diagnostic efficacy of MRE in the staging liver fibrosis. Results: The shear stiffness of the normal group and the pathological group were (1.97±0.43) kPa and (4.05±1.70) kPa, with statistical significance(t=-8.518, P<0.001). The AUC of MRE for diagnosising ≥F1, ≥F2, ≥F3 and F4 liver fibrosis in NAFLD patients was 0.92, 0.94, 0.95 and 0.99, respectively, all of which were higher than that of NFS(0.74, 0.81, 0.85 and 0.91, respectively). Conclusion: MRE is a reliable tool for the evaluation of different stages of fibrosis in NAFLD patients.
ZHANG Xian-yi,JI Ruo-yun,CAI Xiao-li, et al. Evaluation of non-alcoholic fatty liver disease and prediction of liver fibrosis by 3.0T magnetic resonance elastography[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(12): 859-862.
[1]Venkatesh SK, Yin M, Ehman RL. Magnetic resonance elastography of liver: technique, analysis, and clinical applications[J]. J Magn Reson Imaging, 2013, 37(3): 544-555.
[2]Shi Y, Xia F, Li QJ, et al. Magnetic Resonance Elastography for the Evaluation of Liver Fibrosis in Chronic Hepatitis B and C by Using Both Gradient-Recalled Echo and Spin-Echo Echo Planar Imaging: A Prospective Study[J]. Am J Gastroenterol, 2016, 111(6): 823-833.
[3]Shi Y, Guo Q, Xia F, et al. MR elastography for the assessment of hepatic fibrosis in patients with chronic hepatitis B infection: does histologic necroinflammation influence the measurement of hepatic stiffness?[J]. Radiology, 2014, 273(1): 88-98.
[4]Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions[J]. Am J Gastroenterol, 1999, 94(9): 2467-2474.
[5]Angulo P, Hui JM, Marchesini G, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD[J]. Hepatology, 2007, 45(4): 846-854.
[6]Hassan K, Bhalla V, El Regal ME, et al. Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic[J]. World J Gastroenterol, 2014, 20(34): 12082-12101.
[7]De Minicis S, Day C, Svegliati-Baroni G. From NAFLD to NASH and HCC: pathogenetic mechanisms and therapeutic insights[J]. Curr Pharm Des, 2013, 19(29): 5239-5249.
[8]Asbach P, Klatt D, Hamhaber U, et al. Assessment of liver viscoelasticity using multifrequency MR elastography[J]. Magn Reson Med, 2008, 60(2): 373-379.
[9]Huwart L, Sempoux C, Vicaut E, et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis[J]. Gastroenterology, 2008, 135(1): 32-40.
[10]Kral JG, Thung SN, Biron S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis[J]. Surgery, 2004, 135(1): 48-58.
[11]Chen J, Talwalkar JA, Yin M, et al. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography[J]. Radiology, 2011, 259(3): 749-756.
[12]梁淑文，王晓英，屈昌民，等. 非酒精性脂肪性肝病患者胰岛素抵抗与肠道菌群失调相关性研究[J]. 中国医药，2016，11（1）：83-86.
[13]Bohte AE, de Niet A, Jansen L, et al. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C[J]. Eur Radiol, 2014, 24(3): 638-648.
