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| Relationship between metabolic parameters of 18F-FDG PET/CT and clinicopathological features related to endometrial carcinoma |
| CHEN Dan-dan1, LOU Yun-long1, SONG Li1, CHEN Wen-zhong1, ZHANG Ming1, LI Quan1, LIN Wei1, WANG Quan-shi2 |
| 1. Department of Nuclear Medicine, Meizhou People’s Hospital, Meizhou Guangdong 514031, China;
2. PET Center, Nanfang Hosptial, Southern Medical University, Guangzhou 510515, China |
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Abstract Objective: To evaluate the relationship between metabolic parameters of primary endometrial carcinoma and clinicopathological characteristics of patients. Methods: A retrospective analysis of preoperative 18F-FDG PET/CT check of the clinical data of 78 examples patients with endometrial carcinoma, determined the 40% SUVmax of primary endometrial carcinoma as the threshold in transection, sagittal and coronal plane for volume segmentation of lesion. Then we measured the primary focal SUVmax, metabolic volume(MTV) and total lesions glycolysis(TLG). Results: The maximum diameter, SUVmax, MTV and TLG were 3.0 cm(1.5 cm, 7.5 cm), 13.0(3.8, 33.0), 9.0 cm3(1.5 cm3, 56.0 cm3) and 61.8 g(8.3 g, 463.6 g), respectively. SUVmax, MTV and TLG of different histological grades and uterine infiltration depth were statistically significant(P＜0.05), and MTV and TLG of different FIGO stages and lymph node metastasis were statistically significant(P＜0.05). SUVmax, MTV and TLG were positively correlated with tumor maximum diameter, uterine infiltration depth and tumor tissue grading(P＜0.05), MTV and TLG were positively correlated with FIGO stage and lymph node metastasis(P＜0.05), and TLG had the highest correlation coefficient with tumor maximum diameter. Conclusion: 18F-FDG PET/CT metabolic parameters, especially TLG, have a good correlation with the clinicopathological features of endometrial carcinoma.
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Received: 09 October 2019
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