ARFI在婴儿胆道闭锁鉴别诊断及评价肝纤维化程度中的应用价值

doi:10.12117/jccmi.2020.07.011

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Abstract Objective: To investigate the diagnostic value of acoustic radiation force impulse(ARFI) in biliary atresia(BA) and infantile hepatitis syndrome jaundice(IHS), and to study whether the elastic value measured was related to liver fibrosis. Methods: Forty infants with BA, 35 infants with IHS and 25 normal infants underwent two-dimensional ultrasound by Siemens Acuson S3000 color Doppler ultrasound. We used its ARFI technique to measure the liver elasticity of three groups of infants shear wave velocity(SWV) and compared between groups. The pathological stage(F0, F1, F2, F3 and F4) of liver fibrosis was confirmed by liver puncture biopsies or surgery and pathology. SWV of different hepatic fiber stages were compared. Correlation between SWV and pathological stages of liver tissue fibrosis was also analyzed. Results: The SWV value of liver in BA jaundice group was (1.98±0.31) m/s, that in IHS group was (1.13±0.21) m/s, and that in normal group was (1.10±0.24) m/s. There was significant difference among BA group, IHS group and normal group(F=10.958, P＜0.05). There was no significant difference in SWV level between IHS group and normal group(t=1.431, P=1.34). There were significant differences in liver SWV among groups F0, F1, F2, F3, F4 varying degrees of hepatic fibrosis(H=14.307, P＜0.05), there was a significant positive correlation between SWV measured values and liver fibrosis in different pathological stages(r=0.932, P＜0.05), liver fibrosis grade increased and SWV measured values increased. Conclusion: ARFI, as a noninvasive and quantitative method for evaluating the degree of liver fibrosis, provides a basis for differential diagnosis of jaundice in infants and can objectively assess the disease progression and prognosis of infants with biliary atresia.

Key words： Biliary atresia Liver cirrhosis Ultrasonography, Doppler, color

Received: 18 December 2019

PACS:	Ｒ657.44
	Ｒ657.31
	R445.1

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	Articles by authors
	YU Rui-na
	HUA Shao-hua
	HE Xiao
	LI Yan
	CHEN Yang

Cite this article:

YU Rui-na,HUA Shao-hua,HE Xiao, et al. Application of ARFI in differential diagnosis of biliary atresia and evaluation of hepatic fibrosis in infants[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(7): 500-502.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.07.011 OR http://www.jccmi.com.cn/EN/Y2020/V31/I7/500

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