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| Automatic preparation of 11C-N-mythyl-3-amino-1, 2-propanediol and study of rat liver in PET/CT imaging |
| CHEN Xi, YANG Meng-yi, CAO Li, XIN Jun |
| Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China |
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Abstract Objective: To develop a fully automatic synthesis for the preparation of aquaglycerporin imaging agent 11C-N-mythyl-3-amino-1, 2-propanediol, and to study the liver uptake in rat using PET/CT. Methods: 11C-N-mythyl-3-amino-1, 2-propanediol was automatically prepared by using TRACERlab FX C Pro system of GE Healthcare and dynamic liver scans were observed on rats, which were injected by the molecular probe 11C-N-mythyl-3-amino-1, 2-propanediol. The changes of distribution of them in liver with time elapse were observed and the curve of time-activity was plotted. Results: The synthesis efficiency of the probe was over 50%, the radiochemical purity was over 98%, the time for the process was about 30 min. The scans of PET/CT showed the distribution of the probe in liver were clear and the radioactivity decreased significantly with time going. Conclusion: The automatic preparation in producing the probe of high radiochemical is simple and easy to control, and the preclinical study of rat liver may be carried out with the new probe.
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Received: 29 March 2018
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