Abstract Objective: To analyze and discuss the prenatal MRI features and diagnostic value of the fetal cavum septum pellucidum and its associated neurological abnormalities. Methods: From June 2015 to June 2018, 2 361 cases of fetuses from Sichuan Provincial Women and Children Hospital were included in our research. All the fetuses received 1.5T MR and ultrasonography(US) examination. We gathered the clinical information and analyzed the MR imaging. Results: 332 fetuses detected by MRI examination of fetal head revealed cavum septum pellucidum and associated nervous system abnormalities. In these cases, ultrasonography indicated 212 cases of cavum septum pellucidum. The age of the maternal and gestational week was 17~41 years old and 21~39W+3, respectively. MRI presented 221 cases of fetuses with pure cavum septum pellucidum abnormality, including 8 of complete absence of cavum septum pellucidum, 7 cases of partial absence, 92 cases of broadening, and 114 cases of narrowing. One hundred and eleven cases of fetus with cavum septum pellucidum anomaly combined with other neurological abnormalities, including 68 cases of corpus callosum complete absence, 16 cases of corpus callosum partial absence, 3 cases of visual-septal dysplasia, 9 cases of holoprosencephaly（HPE, including 2 alobar HPE, 2 semilobular HPE and 5 lobar HPE), 3 cases of Schizencephaly, 4 cases of brain injury, 4 cases of hydrocephalus, 2 cases of multiple malformations and 2 cases of porencephaly. Conclusions: MRI findings and presentations of fetal cavum septum pellucidum and combined neurological abnormality were characteristic. MRI has obvious advantages over US, which can manifest fetus central nervous system abnormalities not detected by US. MRI can diagnose more accurately and improve the accuracy of prenatal diagnosis of fetal central nervous system abnormalities so that reduce the birth rate of children with major defects.
TAO Yuan-ping,KANG Min,CAO Qian, et al. The value of prenatal diagnosis for abnormality of fetal cavum septum pellucidum by MRI[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(7): 487-494.
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