Value of technetium-99m-labeled HL91 hypoxia imaging in lung cancer
ZHAO Chang-jiu1, YANG Zhi-jie2, FU Peng2, ZHANG Rui2
1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 2. Department of Nuclear Medicine, First Hospital of Harbin Medical University, Harbin 150001, China
Abstract：Objective: To observe the uptake character of 99Tcm-HL91 in lung cancer. At the same time we evaluated the clinical value of hypoxia imaging in detecting oxygen status of neoplasms. Methods: Twenty different pathologic lung cancer patients and four lung benign tumor patients underwent SPECT imaging at 1h, 4h and 24h respectively after injecting 99Tcm-HL91. On the transaxial view, lesion-to-normal tissue background ratios(TUR) were measured by drawing ROIs semiquantitatively for 99Tcm-HL91 uptake. Results: With time going, TUR in malignant tumors increased gradually, while in benign tumors the TUR achieved peak value after 4h and then decreased. There were different TUR in different pathologic tumor tissues. Conclusion: Technetium-99m-labeled HL91 hypoxia imaging of lung cancer can be used to judge the oxygen status of neoplasms. This imaging technique can also be used to predict the histologic type and its malignant degree.
2006, Vol. 17 
