Abstract：Objective: To review CT and MRI feature of primary intracerebral malignant lymphoma(PICML) and to assess the role of the gamma knife radiosurgery in the treatment of PICML. Methods: Eighteen patients with pathology proven PICML were treated with gamma knife radiosurgery from September 1999 to September 2005. They were treated at 40%~50% isodose curve and the tumor margin dose is 13~23Gy. The average margin dose was 16Gy. Eighteen patients with 24 leisons were followed up for 6~30 months with mean 18 months. Results: All lesions treated with gamma knife radiosurgery diminished in size or disappeared within one or two months after treatment, and the neurological deficits had improved dramatically. The local control rate is 100% in the near future. Conclusion: Gamma knife is a safe and effective treatment for PICML, it can relieve neurological symptoms, has a higher local control rate and improves the quality of life.
2006, Vol. 17 
