Abstract:Objective: To study the relationship between clinical manifestation and hand X-ray in rheumatoid arthritis. Methods: Two groups are divided, one was A group: 30 cases RA patients with grade I X-ray, and B group: 26 cases RA patients with grade II and above X-ray. Levels of ESR, CRP, RF and IgG were detected. Result: There were no difference of ESR and CRP levels between the two groups, but there were significant difference of RF and IgG levels between the two groups(P<0.05). Conclusion: There was closely relationship between RF, IgG levels and the damage degree of bone and joint. It was very important to take hand X-ray examination for early diagnosis and prognosis of RA patients.