Comparison of combination specification of the different tumor cell with RGD peptide
JIA Ying-ying1, QIAN Hai-li2, TANG Meng1, ZHAO Zhou-she3, LI Hong-li3, XIN Jun4, ZHANG Li-sheng5, LIN Chen2
1.Department of Nuclear Medicine, Cancer Hospital, PUMC, CAMS, Beijing 100021, China;2.State Key Laboratory of Molecular Oncology, Cancer Institute, PUMC, CAMS, Beijing 100021, China;3.GE Healthcare China, Beijing 100176, China;4.Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China;5.Center of Pre-clinical Study, Cancer Institute, PUMC, CAMS, Beijing 100021, China
Abstract：Objective: To get the αvβ3 receptor combination information of the different tumor cells with RGD peptide by vivo and vitro method, so as to guide clinical molecular imaging research. Materials and Methods: Comparison combination specification of the pancreas tumor cell, hepatic tumor cell, intestine tumor cell and cervix tumor cell with FITC-HYNIC-RGD, and acquisition data for the xenograft mice model of breast tumor and hepatic tumor cell after IV injection of 99mTc-HYNIC-RGD. Results: Combination number of the pancreas tumor cell, hepatic tumor cell is higher than intestine tumor cell and cervix tumor cell with FITC-HYNIC-RGD. The uptake of breast tumor cell with 99mTc-HYNIC-RGD is 40% higher than that of hepatic tumor cell after injection. Conclusion: Combination of the pancreas tumor cell, hepatic tumor cell with FITC-HYNIC-RGD is the highest. Uptake of breast tumor with xenograft mice model is higher than hepatic tumor after injection of 99mTc-HYNIC-RGD.
2008, Vol. 19 
