Abstract：Objective: To analyze the imaging characteristics of tuberous sclerosis complex(TSC) with multiple organ impairment in multiple systems which might help improving the diagnostic efficacy． Methods: Clinical presentation and imaging data of 10 TSC with multiple organ impairment confirmed in clinic were retrospective analyzed, so as to study the extracranial manifestations and pathological types. Results: All the 10 cases were accompanied with typical subependymal nodules, one with subependymal giant cell astrocytoma. Bilateral multiple renal angiomyolipomas(AML) were proven in seven cases with one case of bilateral multiple cysts found concomitantly, intratumoral aneurysm in one case, multiple hepatic AML in one case, pulmonary lymphangioleiomyomatosis in two cases, cardiac rhabdomyosarcomas in two cases with one had congenital anal malformation, pancreatic endocrine neoplasm in one case and knee subcutaneous fibroma with joint effusion in one case. Conclusion: TSC involves multiple organs besides subependymal nodules. Hence, better understanding of these imaging manifestations permits a more specific and accurate diagnosis.
2014, Vol. 25 
