Application of multi-b-value DWI in the differential diagnosis of benign and malignant liver tumor
Aliya·Aizezi1, Saifuding·Keyoumu2, WANG Lu-wei1, WANG Hong1, MA Jing-xu1, JIA Wen-xiao1
1. Department of Imaging Center, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China;2. Department of Gastroenterology, the Third Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China
Abstract：Objective: To study the value of multi-b-value DWI sequence and ADC value as biological markers in the differential diagnosis of benign and malignant tumors in the liver. Methods: Fifty-two patients with liver tumors confirmed by comprehensive imaging examination and biopsy(7 cases of liver cancer and liver metastases in 16 cases, liver hemangioma in 18 cases, 11 cases of hepatic cysts) were chosen to take DWI scan of multiple b values and conventional MRI. ADClow, ADChigh, ADCperf, ADC3b and ADC10b value were calculated and difference between benign and malignant tumors was analyzed. The receiver-operating characteristic curve(receive operating characteristic curve, ROC) was established. Results: The difference of ADC value between benign and malignant liver lesions was significantly(P<0.05), but the difference between liver cancer and liver metastases, liver hemangioma and liver cyst showed no statistical significance(P>0.05). The ADC value of tumor between benign and malignant lesions had statistical difference(P<0.05), but no significant difference was found between benign tumors(P>0.05). The ADC values of various liver diseases was statistically different with 10b and 3b(P<0.05). With b value of low, the ADC values of different liver tumors showed no statistical significance(P>0.05). The sensitivity, specificity were 96.6％, 87％ and 93.1％, 82.6％ respectively, when using a threshold ADC of less than 0.102×10-3 s/mm2, 0.285×10-3 s/mm2 in group of 10b and 3b, respectively. Conclusion: Multi-b-value DWI sequence can help in the identification of benign and malignant tumor diagnosis through multiple quantitative parameters from tumor microcirculation and cell metabolism of liver, especially the ADC10b, ADC3b, ADChigh and ADCperf values.
2014, Vol. 25 
