Volume change of the mesial temporal structure and the relationship between the volume variety and clinical factors in temporal lobe epilepsy
ZHANG Li-hua, YANG Ning, LU Jing-jing, FENG Feng, YOU Hui, JIANG Bo
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China
Abstract：Objective: To explore the volume change of hippocampus, amygdala and entorhinal and the relationship between the volume change of the mesial temporal structure and clinical factors in temporal lobe epilepsy(TLE). Methods: To measure the volume of hippocampus, amygdala and entorhinal of 117 TLE patients with MRI and explore the relationship between the volume change and clinical factors. Results: The ipsilateral volume of hippocampus in unilateral TLE were significantly lower than the contralateral side. In TLE with hippocampal sclerosis the volume of the ipsilateral entorhinal cortex were significantly lower than the contralateral. The volume of amygdala were not significantly different. The degree of hippocampus, amygdala volume reduction was not related with the frequency of simple partial seizures, age of seizure onset, duration of seizure and history of febrile convulsions. The degree of entorhinal cortex reduction was related with the frequency of simple partial seizures. Conclusions: The vulnerability of mesial temporal structure were different.
2008, Vol. 19 
