Abstract：Objective: To explore the characteristics of time-signal intensity curve(TIC) and the differences in perfusion parameter of uterine cervix cancer and normal uterine cervix. Methods: MRI routine scanning and perfusion imaging were performed in 43 patients with uterine cervix cancer and 23 patients without uterine cervix cancer. Data of MRI perfusion imaging in ROI were derivatized into perfusion parameter by Functool software package, and drew into revised TIC by Excel 2003, the differences of TIC and perfusion parameter in both groups were analysed. Results: In 43 patients with uterine cervix cancer and 23 patients without uterine cervix cancer, the shape of TIC and revised TIC of each group were similar, they showed an obvious steep up slope, a long plateau after peak value. Compared to normal uterine cervix group, the upslope of revised TIC of uterine cervix cancer groups were steeper; among MRI perfusion parameters, the median of the PH value had no difference between the normal cervix group and uterine cervix cancer group(P=0.0687), PEI and MSI in obvious enhancement areas of uterine cervix cancer group were higher than those of normal cervix group(P=0.0010, 0.0013, respectively), but TTP were shorter(P=0.0250). Conclusion: TIC can directly describe the difference in blood perfusion between uterine cervix cancer and normal uterine cervix overall, and perfusion parameters can accurately reflect the hemodynamics characteristics of uterine cervix cancer.
2009, Vol. 20 
