Abstract：Objective: To investigate the clinical value of PET/CT for the therapeutic efficacy of proton radiation therapy of body malignant tumors. Methods: Twenty-two patients with body malignant tumors, all are confirmed by pathology or clinic. The 18F-FDG PET/CT scan was performed both before and after proton radiation therapy. With maximal standard uptake value(SUVmax) to evaluate the efficacy of the treatment, conventional CT imaging and clinical follow-up results were analyzed after proton radiation therapy. Results: ①Before proton radiation therapy, 46 lesions were found in the PET/CT imaging of 22 cases with tumor. SUVmax is between 6.9~37(16.36±9.35) and 38 lesions were found in the conventional imaging. ②After proton radiation therapy, the metabolic activity of 46 lesions is decreased with SUVmax dropped 24%~88% between 2.5~24(6.64±5.37). CT and conventional imaging showed that 41%(19/46) tumors were disappeared or reduced, and 59%(27/46) of the tumor did not change significantly. Clinical follow-up of 3~9 months confirmed that 46 lesions have been effectively controlled after the proton radiotherapy. Conclusion: PET/CT can early and effectively evaluate the therapeutic efficacy of proton radiation therapy.
2008, Vol. 19 
