Quantitative tissue velocity imaging myocardial velocity gradient in assessment of left ventricular diastolic function in patients with thoracic radiotherapy
ZHANG Lian-zhong, ZHANG Na, LIU Lin, WU Xiao-cui, HAN Qian, WANG Yue-wei, WANG Wen-yu, NIU Bo
Henan Provincial People’s Hospital, Zhengzhou 450003, China
Abstract：Objective: To evaluate the clinic experimental value of quantitative tissue velocity imaging(QTVI) in assessing left ventricular diastolic function in patients who had thoracic radiotherapy. Methods: There were 40 patients with thoracic radiotherapy and 20 healthy controls in this study. Myocardial velocity gradient（MVG） and conventional echocardiographic parameters were performed in 60 subjects. According to the process of radiotherapy, the 40 patients were divided into two groups: group A: radiotherapy time was 2.7～3.3 weeks, radiotherapy dose was 30～40Gy; group B: radiotherapy time was 4.1～5.5 weeks, radiotherapy dose was 50～60Gy. Off line profiles of the left ventricular regional diastolic velocity along long axis in the 40 patients and 20 healthy subjects were analyzed by QTVI. Regional diastolic velocities(Ve, Va) were measured at each segment of left ventricular basal, middle and apical levels. MVG were calculated respectively. Results: ①Left ventricular inflow velocity index(E/A) of group A and group B was significantly lower than that in the control group(P＜0.05); There was significant difference of E/A ratio between group B and group A(P＜0.05). ②MVG1, MVG2 and MVG3 of group A and group B in anterior wall, anterior septal, posterior wall were significantly lower than those in the control group(P＜0.05); MVG1, MVG2 and MVG3 of group B in anterior wall, anterior septal, posterior wall were lower than those in group A(P＜0.05); MVG1, MVG2 and MVG3 of group A and group B in left lateral wall, posterior wall, septal wall were lower than those in the control group(P＞0.05)； MVG1, MVG2 and MVG3 of inferior and posterior walls in all groups had no significant difference(P＞0.05). Conclusion: The results in this study demonstrated that regional left ventricular diastolic function was decreased in patients with thoracic radiotherapy. MVG derived from myocardial QTVI could assess left ventricular diastolic function correctly, which could offer a new approach for evaluation of myocardial function.
2008, Vol. 19 
