Abstract：Objective: To study the expression of CD31 and CD34 in nodular goiter and thyroid adenoma, and to provide the pathologic bases for differentiating nodular goiter from thyroid adenoma with contrast-enhanced ultrasound. Methods: CEUS process of 30 cases of nodular goiter and 30 cases of thyroid adenoma was retrospectively analyzed, and the time-intensity curve was analyzed by TomTec software. Immunohistochemical staining was performed to evaluate the MVD in surgical specimens. Quantitative parameters and MVD were assessed by the Spearman’s Rank correlation analysis. Results: After enhancement, 23 cases of nodular goiter showed isoechoic, 4 cases of nodular goiter showed hyperechoic, 3 cases of nodular goiter showed hypotonic, 29 cases of thyroid adenoma showed hyperechoic, and 1 case of thyroid adenoma showed isoechoic. There was significant difference in mTT and IMAX. RT and TTP were not statistically significant. Thyroid adenoma had rich microvessels. RT, TTP and mTT showed negative correlations while IMAX showed positive correlation with MVD. Conclusions: CEUS enhancement patterns are different between nodular goiter and thyroid adenoma, and it helps the diagnosis and differential diagnosis.
2015, Vol. 26 
