摘要目的：运用Meta分析方法评价磁共振弹性成像（MRE）对肝纤维化分期的诊断价值。方法：对PUBMED，EMBASE，Web of Science，Cochrane Library数据库中有关MRE评价肝纤维化分期的英文文献进行筛选。应用诊断试验QUADAS-2质量评价系统对纳入文献进行质量评价。应用Stata 12.0软件对入选文献的试验数据进行合并分析。结果：18篇文献符合纳入标准。MRE诊断F≥1、F≥2、F≥3、F=4的合并敏感度分别为0.87、0.9、0.94、及0.98，合并特异度分别为0.95、0.94、0.91、及0.94，SROC曲线下面积分别为0.97、0.97、0.96、及0.98。结论：MRE对肝纤维化各分期具有较高的诊断价值。
Abstract：Objective: A Meta-analysis was performed to investigate the diagnostic value of Magnetic Resonance Elastography(MRE) for different stages of hepatic fibrosis. Methods: English articles related to MRE diagnosis for hepatic fibrosis from various data resources including PUBMED, EMBASE, Web of Science, and Cochrane Library database were collected and evaluated. Using a checklist based on the Quality Assessment for Studies of Diagnostic Accuracy-2(QUADAS-2), the methodological quality of each study was characterized. Stata 12.0 software was used to synthetically analyze the experimental data from different English literatures. Results: 18 studies were finally collected which met all inclusion criteia. The pooled sensitivity and specificity for F≥1, F≥2, F≥3, and F=4 were 0.87, 0.9, 0.94, 0.98 and 0.95, 0.94, 0.91, 0.94, and the areas under curve(AUC) were 0.97, 0.97, 0.96, and 0.98, respectively. Conclusion: MRE has a higher diagnostic value for determining different hepatic fibrosis stages.
王 威;温 锋;赵相轩;石 喻;王悦人;郭启勇. 磁共振弹性成像评价肝纤维化分期的Meta分析[J]. , 2015, 26(5): 329-333.
WANG Wei;WEN Feng;ZHAO Xiang-xuan;SHI Yu;WANG Yue-ren;GUO Qi-yong. A Meta-analysis of magnetic resonance elastography for the staging of hepatic fibrosis. , 2015, 26(5): 329-333.
2015, Vol. 26 
