Abstract：Objective: To study the feasibility and method of magnetic resonance perfusion weighted imaging(MR PWI) in children’s brain. Methods: GE 1.5T HDx echo speed plus MRI scanner were used and double dosage(0.2mmol/kg) Gd－DTPA was given. In the study group, 45 children underwent MR PWI with the injection speed ranged from 2～4ml/s according to the limit of the vein. In control group, 20 adults underwent MR PWI with the injection speed of 2～4ml/s. After the MR PWI scan, negative enhancement integral(NEI) maps were obtained. NEI values and relative NEI(rNEI) were studied in NEI maps. Results: The study showed that the children with body weight <20kg and Gd－DTPA injection speed of 3ml/s or with body weight >20kg and injection speed 3～4ml/s could get satisfactory PWI curves. Children <10kg with injection speed of 2ml/s could get available PWI curves. The NEI values of the studied group had a marked standard deviation(13.69～22.54) and there were significant statistical differences between the two groups(P＜0.001). But rNEI of studied group had a slight standard deviation(0.05～0.08) and there were no significant statistical differences between the two groups(P＞0.001). Conclusion: MR PWI could be used in the research of children brain perfusion if the injection speed was high enough. This study is very important to the research of cerebral MR PWI in pediatrics.
郭岳霖;张远芳;饶海冰;郑文斌;刘国瑞. 儿童脑部磁共振灌注成像技术的初步研究[J]. , 2011, 22(7): 457-460.
GUO Yue-lin;ZHANG Yuan-fang;RAO Hai-bing;ZHENG Wen-bin;LIU Guo-rui. The study of MR PWI in the brain of children. , 2011, 22(7): 457-460.
2011, Vol. 22 
