The correlative study between MR classification of hemorrhagic transformation of non-thrombolytic therapy brain infarction and clinical outcome
BEI Gui-guang1, LI Song-bai2, MA Hong1, CHENG Zhi-liang1, JIANG Bao-guo3, LI Xiang4
1. Department of Radiology, The 202th Hospital of PLA, Shenyang 110812, China;2. Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;3. Department of Radiology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110025, China;4. Department of Radiology, the Second Affiliated Hospital of Dalian Medical University, Dalian Liaoning 116014, China
Abstract：Objective: We intend to ①establish a MR classification method of hemorrhagic transformation(HT) of brain infarction; ②investigate the correlative relation between MR classification of HT of brain infarction and clinical outcome. Then investigate the applicative value of MR classification method of brain infarction HT on assessment clinical outcome. Materials and Methods: Review 421 non-thrombolytic therapy for acute brain infarction cases, who were examined and cured in our hospital from October 2007 to November 2009. All cases had high signal on DWI images performed at 3~7 days after stroke onset. Thirty-one HT cases were classificated by our own MR classification method. The correlative relation between MR classification of HT of brain infarction and clinical outcome were investigated. Disability and function repaired were assessed after 3 months using the modified Rankin score(mRs). Outcomes in patients with and without HT were compared by χ2 test. t test was used between two groups. Results: In all 421 cases, 31 cases(7.4%) had HT, grade Ⅰ: 10 cases(2.34%), grade Ⅱ: 4 cases(0.95%), grade Ⅲ: 17 cases(4.0%). 3-month mRs: 165 cases(39.2%) had disability(mRs 3~5) or died， 35 cases（8.3%）died. In 31 HT cases, 21 cases(67.7%) had disability or died. Grade Ⅱ HT, grade Ⅲ HT had significant relationship with poor outcomes. Conclusions: 7.4% non-thrombolytic therapy for acute brain infarctions had HT, brain stem or cerebellum HT, large area HT had significant relationship with poor outcomes; MR classification method of HT of non-thrombolytic therapy for brain infarction had significant relationship with outcomes.
2011, Vol. 22 
