Small renal cell carcinoma 4D THRIVE dynamic enhanced scanning parameters and the correlation with tumor angiogenesis
LI Xiao-fu1, GAO Ying2, ZHAO Ming1, ZHANG Tie-cheng1, FU Kuang1
1. Department of MRI, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;2. Department of Radiology, Harbin Institute of Technology, Harbin 150001, China
Abstract：Objective: To investigate the relationship of small renal cell carcinoma 4D THRIVE dynamic enhanced parameters and tumor angiogenesis. Methods: Thirty cases clinically suspected small renal cell carcinoma patients were examined by 4D THRIVE dynamic enhanced scanning, tumor area of interest ROI and tumor-adjacent kidney tissues of dynamic enhanced parameters: the biggest enhanced slope(Smax), peak height(PH) and time-to-peak(Tpeak) were calculated respectively. Pathologic specimens were performed by immunohistochemical staining, microvascular density(MVD) count and vascular endothelial growth factor(VEGF) expressing were examined, small renal cell carcinoma of each dynamic enhance parameters were correlated with MVD and VEGF. Results: The enhancement parameters Smax(r=0.707, P<0.01), PH(r=0.687, P<0.01) correlated positively with MVD. Tpeak(r=-0.413, P<0.05) correlated negatively with MVD. The mean value of MVD(63.07±14.73) field in patients with small renal cell carcinoma were siginificantly higher than tumor-adjacent kidney tissues(P=0.002), 67%(20/30) small renal cell carcinoma VEGF expression was positive, higher than tumor tumor-adjacent kidney tissues(P=0.001). Conclusion: Small renal cell carcinoma 4D THRIVE dynamic enhanced scanning, some parameters correlated positively with MVD, VEGF. It has an important value in small renal cell carcinoma angiogenesis.
2011, Vol. 22 
