Applications of MR whole body DWI in multiple bone tumors
LIU Shuai1, ZHAO Wei-dong1, CHEN Peng2, ZHANG Hong-yu1, CAI Lin1
1. Department of Medical Imaging, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China;2. Department of Nuclear Medicine, the First People’s Hospital of Lianyungang, Lianyungang Jiangsu 222002, China
Abstract：Objective: To investigate the value of whole body DWI(WB-DWI) in differential diagnosis of multiple bone metastases and multiple myeloma. Materials and Methods: Fifty-seven cases with multiple bone tumors and 12 cases normal volunteers underwent WB-DWI. Furthermore, the signal characteristic and ADC values of the thoracic, lumbar vertebrae, and llilac bone were analyzed and measured respectively. In addition, the detection frequency for searching primary tumors in patients with multiple osseous metastases was calculated. Results: Multiple osseous tumors demonstrate abnormal high signals on WB-DWI. The ADC value of multiple osseous metastases were higher than that of multiple myeloma. Meanwhile, the ADC value of multiple myeloma and multiple osseous metastases were markedly higher than that of normal bone. The difference was significant in ADC values between multiple myeloma and multiple osseous metastases(P<0.01). The detection frequency for searching primary tumors in patients with multiple osseous metastases was 74.5%(35/47). Conclusion: Multiple osseous metastases and multiple myeloma can be differentiated by quantitative analysis with ADC value. The WB-DWI can demonstrate primary tumors, which also can help to differentiate multiple osseous metastases and multiple myeloma.
2011, Vol. 22 
