Abstract：Objective: To study the endothelial dysfunction in early-stage chronic kidney disease(CKD) patients and to explore the relationship between Flow-Mediated Dilation(FMD) and renal pathology. Methods: Sixty subjects were divideded evenly into 3 groups: group A: normal control group; group B: renal patients without renal insufficiency; group C: renal hypertension patients without renal insufficiency. Each group underwent ultrasonographic examination of brachial artery diameter in the basic condition and the reactive hyperaemia. All renal patients had renal biopsy under ultrasound guidance. The degree of renal tissue damage made semiquantitative integral. We correlated endothelial function with age, pressure and renal pathology. Results: The FMD was impaired significantly in group C than that in group A and group B, but there was no difference in group A and group B; The FMD had a high correlation with systolic blood pressure, glomerular and interstitial damage index but no correlation with age and diastolic pressure. Conclusions: The endothelial function is impaired in renal hypertension patients without renal insufficiency; As the endothelial function becoming worse, renal pathological damage increased accordingly; Evaluation of the endothelial function by the high-resolution ultrasonography in early-stage CKD patients have clinical improtance．
王 媛;童明辉;鲁虹霞;陈斌娟;王小锋;李 莉. 早期慢性肾病患者血管内皮功能及肾脏病理相关性研究[J]. , 2011, 22(12): 858-859.
WANG Yuan;TONG Ming-hui;LU Hong-xia;CHEN Bin-juan;WANG Xiao-feng;LI Li. The research of endothelial function and renal pathology in early-stage chronic kidney disease(CKD) patient. , 2011, 22(12): 858-859.
2011, Vol. 22 
