Comparative study in primary brain B-cell lymphoma using diffusion weighted imaging and multi-phases contrast enhancement of MR
LIU Gan-hui1, CHEN Zhen-song1, CHENG Ying1, CHEN Ye-yuan2, WANG Hong-zhuo1, SUN Wan-qin1, CAI Shu-feng1, YANG Li-juan1, GONG Hong-han2, PAN Gao-sheng1
1. Department of Radiology, Yuebei People’s Hospital, Shaoguan Guangdong 512026, China;2. Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Abstract：Objective: To investigate MRI characteristics of the primary brain B-cell lymphoma(PBBL) so as to diagnose accurately. Methods: Seventy-one patients underwent MRI examination, and they were found to have the single mass in their brain, and then all patients were performed diffusion weighted imaging and contrast enhanced examination at 25 s, 125 s and 185 s after contrast injection, respectively. Depending on pathological data, all patients were divided into groups, ADC values and signal intensity of non-contrast and contrast examination were measured and compared. Results: Fifty-eight patients had entire pathological data and were divided into three groups, including twelve patients with PBBL, 20 glioblastoma and 26 brain metastasis from lung cancer. For all groups, there were no statistical differences found among ADC values and signal intensity in non-contrast examination(P>0.05). In all phases of contrast enhancement examination, mean signal intensity of PBBL were compared with those of the other two groups respectively, relative coefficient between 25 s and 125 s was 1.0, differences were significant(P<0.05), whereas those between 25 s and 185 s, between 125 s and 185 s were not significant(P>0.05). The signal intensity of PBBL at all phases of contrast enhancement was compared with that of glioblastoma, differences were significant in 5 phase points, but compared with brain metastasis of lung cancer, those of PBBL at 11 phase ponts were significant and could be used differential diagnosis. Conclusion: MRI examination by multi-phases contrast enhancement is able to provide more information for differentiating PBBL from glioblastoma and brain metastasis of lung cancer. Meantime, we find that ADC value is not useful to make differential diagnosis of PBBL and other tumors.
2013, Vol. 24 
