Fractional amplitude analysis of low frequency fluctuation in generalized tonic-clonic seizure:a resting state functional MRI study
LIU Guang-yao1, YANG Xiao-ping2, ZHANG Zhe3, JIANG Jian1, HAN Yue-dong2, MA Qiang-hua2, KE Ming3
1.Department of MR, Lanzhou University Second Hospital, Lanzhou 733000, China;2.Department of Imaging Diagnosis, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, China;3.School of Computer and Communication, Lanzhou University of Technology, Lanzhou 730050, China
Abstract：Objective: To explore the whole brain activity features during the interictal time of generalized tonic-clonic seizure(GTCS) using resting state MRI. Methods: Twenty-one GTCS individuals and 21 healthy control subjects, well matched in gender, age, education and handedness, were enrolled as the GTCS group and control group, respectively． A Siemens 3.0T MR scanner was used to acquire all the subjects’ resting state data with GRE-EPI sequence, DPARSF software was used to process resting functional MRI data. fALFF of the two groups were calculated and compared. The correlation between fALFF and NHS3 scores of GTCS was observed. Results: In comparison with the control group, the GTCS group showed reduced fALFF in cingulate gyrus, medial frontal gyrus, right opercula insulae, left supramarginal gyrus(t＝-4.63～-3.88, P<0.01). fALFF was increased in the cerebellum posterior lobe/cerebellar tonsil, right fusiform gyrus, inferior temporal gyrus(t＝5.21～6.04, P<0.01). In addition, fALFF in the left parietal lobe, inferior parietal lobule, right fusiform gyrus, inferior temporal gyrus positively correlated with the NHS3 scores of the patients(P＜0.01), while in the medial frontal gyrus, superior frontal gyrus, left insular lobe superiortemporal gyrus correlated negatively with the NHS3 scores of the patients(P＜0.01). Conclusion: GTCS patients had abnormal activity at the cingulate gyrus, medial frontal gyrus, inferior temporal gyrus, cerebellum posterior lobe, cerebellar tonsil et al, during the interictal time; and these abnormal activities might be related with clinical manifestation and pathophysiology, which may help for explanation of the clinical manifestations and pathophysiological mechanisms in GTCS.
2013, Vol. 24 
