Abstract：Objective: To study the difference of vascular endothelial function by evaluating flow mediated dilation(FMD) of brachial artery and popliteal artery in diabetic kidney disease(DKD) patients with high frequency ultrasound. Methods: Vascular diameter and velocity in baseline and after reactive hyperaemia of brachial artery and popliteal artery were detected with high frequency ultrasound in 20 healthy volunteers, type 2 diabetic mellitus(T2DM) and patients with DKD-V pre-hemodialysis, FMD were calculated and compared between the 3 groups. Results: Difference of brachial artery FMD and popliteal artery FMD between each two groups were significant(P<0.05). Difference of FMD between brachial artery and popliteal artery in each group were significant(P<0.05). The difference between each two groups of brachial artery and popliteal artery FMD were significant(P<0.05) and increased as disease progress. Conclusion: When T2DM involved kidney, endothelial dysfunction of popliteal artery progress faster than brachial artery.
2014, Vol. 25 
