A comparative study of HRCT findings and pathological basis of intralobular lines in coal workers’ pneumoconiosis
1. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
2. Beijing Fengtai Hospital, Beijing 100071, China;
3. National Research Center for Occupational Safety and Health, Beijing 102300, China
Abstract:Objective: To evaluate the imaging features of high-resolution CT(HRCT) and pathological basis in patients with coal workers’ pneumoconiosis(CWP). Methods: Fifty-two fresh lungs from patients with CWP were fixed and inflated by the Heitzman method. The inflated specimens underwent HRCT coronal and transverse planes scanning. Two experienced chest radiologists independently made the diagnosis results. The evaluation parameters included intralobular lines, micronodules, ground-glass opacity(GGO), thickened intralobular septa, crazy-paving pattern, bronchiectasis, and honeycombing. A comparative study of image and pathology was performed on the tissue sections according to the HRCT region of interest. Results: Of the 52 specimens, 21 were excluded because of structure distortion, and 31 were enrolled in this study. In the transverse projection, only 16.1% of the specimens exhibited peribronchovascular predominance, and 38.7% exhibited subpleural predominance. In the coronal view, the incidence of distribution in the upper-zone was only 16.1%. Among the accompanying signs of intralobular lines, micronodules and thickened interlobular septa were the most common observations(100%), followed by GGO(83.9%) and emphysema(80.6%). The intralobular lines on HRCT corresponded to thickened alveolar septa that were associated with coal macules, fibrosis, inflammation, tumors, and serous fluid based on pathology. Conclusion: The intralobular lines of CWP on HRCT correlate with a variety of pathological backgrounds. The thickened interlobular septa are the most frequent accompanying sign.
关春爽1,马大庆1,崔 平2,陈步东1,张岩松3,柳玮华1. 煤工尘肺小叶内线影HRCT与病理的对照研究[J]. 中国临床医学影像杂志, 2015, 26(12): 873-876.
GUAN Chun-shuang1, MA Da-qing1, CUI Ping2, CHEN Bu-dong1, ZHANG Yan-song3, LIU Wei-hua1. A comparative study of HRCT findings and pathological basis of intralobular lines in coal workers’ pneumoconiosis. JOURNAL OF CHINA MEDICAL IMAGING, 2015, 26(12): 873-876.
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