Quantitative analysis of aging changes of human submandibular glands using magnetic resonance imaging
1. Department of Radiology, Affiliated Suzhou Hospital, Nanjing Medical University, Suzhou Jiangsu 215002, China;
2. The Second Affiliated Hospital of Soochow University, Suzhou Jiangsu 215004, China
Abstract:Objective: To explore the age-related characteristics of volumes, T1WI, T2WI, and contrast T1WI signal intensities(SI) and apparent diffusion coefficients(ADC) of submandibular glands. Methods: Three hundred subjects with normal submandibular glands were divided into four different age groups and examined with a 1.5T MR unit. T1WI, T2WI, contrast T1WI and diffusion-weighted MR images(DW MRI) were obtained, and bilateral submandibular glands were segmented manually. Relative signal intensities(RSI) of T1WI, T2WI and enhanced-T1WI and value of ADC were calculated. Results: There was no significance in volumes of submandibular between four different age groups(P>0.05). The ADC of submandibular glands showed a significant difference between the minority and middle age group(P<0.01). The mean submandibular gland volume was higher in males demonstrating a significant difference between genders(t=4.576, P<0.01). No significant differences was observed in all parameters of CSF among four groups(P>0.05). There also was no significant difference between right and left glands in all parameters(P>0.05). Conclusion: Quantitative evaluation of MRI on aging morphological and functional changes of submandibular glands can provide baseline references for salivary glands aging research and differential diagnosis of submandibular gland diseases.
张红丽1,徐 亮2,许建铭1,赵丹蕾2,李晓兵1,张继斌1,沈钧康2,田 野2. 颌下腺增龄性改变的MRI定量分析[J]. 中国临床医学影像杂志, 2016, 27(2): 90-93.
ZHANG Hong-li1, XU Liang2, XU Jian-ming1, ZHAO Dan-lei2, LI Xiao-bing1, ZHANG Ji-bin1, SHEN Jun-kang2, TIAN Ye2. Quantitative analysis of aging changes of human submandibular glands using magnetic resonance imaging. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(2): 90-93.
[1]Saito N, Sakai O, Bauer CM, et al. Age-related relaxo-volumetric quantitative magnetic resonance imaging of the major salivary glands[J]. J Comput Assist Tomogr, 2013, 37(2): 272-278.
[2]Mahne A, El-Haddad G, Alavi A, et al. Assessment of age-related morphological and functional changes of selected structures of the head and neck by computed tomography, magnetic resonance imaging, and positron emission tomography[J]. Semin Nucl Med, 2007, 37(2): 88-102.
[3]Yoshino N, Yamada I, Ohbayashi N, et al. Salivary glands and lesions: evaluation of apparent diffusion coefficients with split-echo diffusion-weighted MR imaging-initial results[J]. Radiology, 2001, 221(3): 837-842.
[4]Kaneda T, Minami M, Ozawa K, et al. MR of the submandibular gland: normal and pathologic states[J]. Am J Neuroradiol, 1996, 17(8): 1575-1581.
[5]许洪敏, 嵇鸣. 干燥综合征的腮腺3.0T MR检查[J]. 中国临床医学影像杂志,2014,25(5):318-320.
[6]Scott J. Quantitative age changes in the histological structure of human submandibular salivary glands[J]. Arch Oral Biol, 1977, 22(3): 221-227.
[7]董绍忠,吴奇光,郑麟蕃. 人颌下腺年龄变化的定量组织学研究[J]. 中华口腔医学杂志,1989,24(1):15-17.
[8]Kurashima C, Hirokawa K. Age-related increase of focal lymphocytic infiltration in the human submandibular glands[J]. J Oral Pathol, 1986, 15(3): 172-178.
[9]Smith CH, Boland B, Daureeawoo Y, et al. Effect of aging on stimulated salivary flow in adults[J]. J Am Geriatr Soc, 2013, 61(5): 805-808.
[10]Yonetsu K, Yuasa K, Kanda S. Quantitative analysis of the submandibular gland using computed tomography[J]. Dentomaxillofac Radiol, 1996, 25(2): 97-102.
[11]柳晓冰,俞光岩,唐广健,等. 人类大涎腺CT值的增龄性改变[J]. 中华口腔医学杂志,1999,34(2):73-75.
[12]Watannbe S, Dawes C. Salivary flow rates and salivary film thickness in five-year-old children[J]. J Dent Res, 1990, 69(5): 1150-1153.
[13]Nagler RM. Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring[J]. Biogerontology, 2004, 5(4): 223-233.
[14]Ono K, Morimoto Y, Inoue H, et al. Relationship of the unstimulated whole saliva flow rate and salivary gland size estimated by magnetic resonance image in healthy young humans[J]. Arch Oral Biol, 2006, 51(4): 345-349.
[15]Boyd ZT, Goud AR, Lowe LH, et al. Pediatric salivary gland imaging[J]. Pediatr Radiol, 2009, 39(7): 710-722.