Abstract：Abstract: Objective: To explore the regional spontaneous activity changes in the whole brain of trigeminal neuralgia(TN) patients using resting-state fMRI. Methods: Resting-state fMRI datasets of 30 TN patients and 20 healthy controls were acquired. The amplitude low-frequency fluctuation(ALFF) and independent-sample t-test were used to compare the brain activity abnormalities between these two groups. Results: In TN patients, we found decreased ALFF in the left superior temporal gyrus and left fusiform, as well as an increased ALFF in the left frontal med orb and left sup motor area. Conclusion: Our results demonstrated the spontaneous activity change underlying TNP, and these abnormalities may contribute to the cognization and emotion of the pain.
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