Dorsolateral putaminal abnormality on magnetic resonance imaging in differentiating#br#
parkinsonism-predominant multiple system atrophy from Parkinson’s disease
ZHENG Kui-hong1, QI Xiao-kun2, LIU Jian-guo2, GUO Yong2, HUANG Min-hua2, MA Lin1#br#
(1.Department of Radiology, PLA General Hospital, Beijing 100853, China;#br#
2.PLA Navy General Hospital, Beijing 100048, China)
(1.Department of Radiology, PLA General Hospital, Beijing 100853, China;
2.PLA Navy General Hospital, Beijing 100048, China)
Abstract：Abstract: Objective: To evaluate the diagnostic value of dorsolateral putaminal abnormality on magnetic resonance imaging(MRI) for differentiating parkinsonism-predominant multiple system atrophy(MSA-p) from Parkinson's disease(PD). Methods: Teen patients with MSA-p, 20 patients with PD were included. All subjects were examined with 3.0T MRI using the conventional and diffusion-weighted protocol. Putaminal atrophy, hypointensity on diffusion-weighted imaging(DWI) associated with a slit-like T2-hyperintense rim on the dorsolateral putamen were evaluated in each item. Results: Putaminal atrophy was found in 60% (6 of 10) of the MSA-p group, in only 10%(2 of 20) of the PD group. Dorsolateral putaminal abnormalities were seen in MSA-p(n=8) group, and none in PD group. The slit-like T2-hyperintense rim and the hypointensity on DWI in the dorsolateral putamen were seen in 80%(8/10) of the MAS-p group, which is significantly higher than PD group(0/20). The specificity and sensitivity of the dorsolateral putaminal abnormality for distinguishing MSA-p from PD was 100% and 80%, respectively. Conclusions: The signal changes including slit-like T2-hyperintense rim associated with hypointensity on DWI in the dorsolateral putamen are specific signs for differentiating MSA-p from PD.
郑奎宏1，戚晓昆2，刘建国2，郭 勇2，黄敏华2，马 林1. 壳核背外侧异常信号在鉴别P型多系统萎缩与帕金森病中的诊断价值[J]. 中国临床医学影像杂志, 2017, 28(5): 305-308.
ZHENG Kui-hong1, QI Xiao-kun2, LIU Jian-guo2, GUO Yong2, HUANG Min-hua2, MA Lin1. Dorsolateral putaminal abnormality on magnetic resonance imaging in differentiating#br#
parkinsonism-predominant multiple system atrophy from Parkinson’s disease. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(5): 305-308.
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2017, Vol. 28 
