源于阿尔茨海默病的轻度认知障碍患者脑结构及#br#
静息态功能磁共振研究进展

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摘要轻度认知障碍（MCI）是介于正常老化与痴呆之间的一种过渡状态，从MCI进展到阿尔茨海默病（AD）痴呆是一个脑功能和脑结构损害不断进展的过程，磁共振成像（MRI）可以无创地观察患者在疾病进展过程中脑结构与功能的变化，因此，近年来借助MRI技术建立新的AD早期诊断方法已成为热点。本文对近年来结构磁共振以及静息态功能磁共振对MCI向AD痴呆转化的研究进行综述。MRI对研究MCI向AD的转化起到了重要作用，为其提供影像学依据，并起到动态监测其进展的作用。

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	李瑜霞1
	李永秋2
	孙宇1
	盛灿1
	李红艳1
	牛海晶3
	韩璎1

关键词 ：阿尔茨海默病, 认知障碍, 磁共振成像

Abstract：Mild cognitive impairment(MCI) is considered as a transitional stage between normal aging and Alzheimer’s disease(AD). It is a gradually progressing process from MCI to AD dementia. The changes of the structure and function in the process of disease progression can be seen noninvasively using MRI technology, so it has become the focus that studies the conversion of MCI to AD dementia using the technology of MRI. The studies of the structural MRI and the resting state functional MRI from MCI to AD dementia in recent years were reviewed in this paper. It has played an important role for MRI in the study of the conversion from MCI to AD, and it has the effect of dynamic monitoring on the progression at the imaging basis.

Key words： Alzheimer disease Cognition disorders Magnetic resonance imaging

收稿日期: 2015-05-06

PACS:	Ｒ745.7
	Ｒ445.2

基金资助:国家自然科学基金项目（项目批号：31371007；81430037；81261120571；30970823）；北京市科委首都市民健康培育项目
（基金资助号Z131100006813022）；凯力康医学研究项目，编号：201206006。

通讯作者: 韩璎

作者简介: 李瑜霞（1980-），女，河北唐山人，主治医师。现工作单位为唐山市工人医院神经内科。E-mail：304425392@qq.com

引用本文:

李瑜霞1，李永秋2，孙宇1，盛灿1，李红艳1，牛海晶3，韩璎1. 源于阿尔茨海默病的轻度认知障碍患者脑结构及#br# 静息态功能磁共振研究进展[J]. 中国临床医学影像杂志, 2016, 27(2): 131-134.
LI Yu-xia1, LI Yong-qiu2, SUN Yu1, SHENG Can1, LI Hong-yan1, NIU Hai-jing3, HAN Ying1. Structural and resting state functional MRI characteristics of patients with #br# mild cognitive impairment due to Alzheimer’s disease. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(2): 131-134.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2016/V27/I2/131

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