Abstract：Objective: To observe neonatal insula development situation and clinical significance by head ultrasound. Methods: Morphological characteristics and areas and perimeters of 212 cases of neonatal insula(at 28～43 weeks’ corrected gestational age(CGA)) were observed and measured by head ultrasound and their correlation with CGA were evaluated with regression analysis. The repeatability and consistency were analyzed with ICC and Bland-Altman analysis. Results: Neonatal insula was inverted triangle in shape, insula gyrus were radially extended upwards, which looked like flower petal. The area and perimeter of neonatal insula strongly correlated with CGA. The regression equations were as follows: area of insula(mm2)=183.7CGA-2 766.1(r2=0.545, P<0.01), perimeter of insula(mm)=12.91CGA-243.66(r2=0.393, P<0.01). The repeatability and consistency of data obtained were all perfect. Conclusion: Transcranial ultrasound can become a routine means in assessing the development of neonatal insula.
陈晓康，陈少华，吕国荣，陈泽坤. 经颅脑超声观测新生儿脑岛的发育及其临床意义[J]. 中国临床医学影像杂志, 2016, 27(10): 698-700.
CHEN Xiao-kang, CHEN Shao-hua, LV Guo-rong, CHEN Ze-kun. The development of neonatal insula observed by head ultrasound and clinical significance. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(10): 698-700.
[1]Meyniel F, Sergent C, Rigoux L, et al. Neurocomputational account of how the human brain decides when to have a break[J]. Proc Natl Acad Sci USA, 2013, 110(7): 2641-2646.
[2]沈笠雪，王磊. 岛叶的结构与功能[J]. 国际神经病学神经外科学杂志，2012，39（4）：393-395.
[3]Afif A, Bouvier R, Buenerd A, et al. Development of the human fetal cortex: study of the gyration from 13 to 28 gestational weeks[J]. Brain Struct Funct, 2007, 212(3-4）: 335-346.
[4]Govaert P, Swarte R, De VA, et al. Sonographic appearance of the normal and abnormal insula of Reil[J]. Dev Med Child Neurol, 2004, 46(9): 610-616.
[5]Egana-Ugrinovic G, Sanz-Cortes M, Figueras F, et al. Differences in cortical development assessed by fetal MRI in late-onset intrauterine growth restriction[J]. Am J Obstet Gynecol, 2013, 209(2): 126-128.
[6]陈晓康，吕国荣，凌乐文. 二维联合三维超声诊断胎儿脑沟脑回发育异常的临床应用价值[J]. 福建医科大学学报，2014，48（3）：205-208.
[7]陈晓康，吕国荣，林惠通. 胎儿脑沟、脑回发育异常的超声检查分析[J]. 中华超声影像学杂志，2010，19（10）：915-916.
[8]陈晓康，吕国荣，李敏，等. 经颅超声观测新生儿小脑蚓部及其临床意义[J]. 临床超声医学杂志，2015，17（6）：392-394.
[9]陈援农，孙丽霞，张艳秋. 小于胎龄儿脑岛的测量[J]. 中国当代儿科杂志，2009，9（11）：733-735.
[10]徐振宏，黄柏青，陈少华，等. 胎儿小脑延髓池扩张的临床预后及意义[J]. 中国超声医学杂志，2012，28（12）：1120-1122.
