临床前期阿尔茨海默病的功能MRI研究进展

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摘要阿尔茨海默病（Alzheimer’s disease，AD）是一个连续的病理生理学过程，在临床症状出现前的数十年，人脑就已产生AD特异性的病理学改变。近年来，借助先进的神经影像学技术和生化检测手段，研究人员逐步发现了各种AD相关的生物学标志物，使得在临床前期诊断AD并实施干预成为可能。功能MRI是目前最常用的脑功能成像技术，可揭示疾病早期的脑功能活动特征。本文就近年来基于功能MRI的临床前期AD研究进行综述。

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	盛灿1
	刘芳1
	韩璎2

关键词 ：阿尔茨海默病, 磁共振成像

Abstract：Alzheimer’s disease(AD) is considered as a continuously pathophysiological process. Special pathological changes of AD has occurred decades prior to the onset of clinical symptoms. Currently, due to the advanced neuroimaging techniques and biochemical tests, variant AD-related biomarkers are gradually identified, making it possible to diagnose AD in the preclinical stage and further intervene the process of the disease. Functional MRI(fMRI), which is helpful to reveal the early brain functional activities in preclinical AD, is the most common form of functional imaging techniques. This review is about researches involving preclinical AD based on fMRI in recent years.

Key words： Alzheimer disease Magnetic resonance imaging

收稿日期: 2017-06-27

PACS:	Ｒ742
	Ｒ445.2

通讯作者: 刘芳，清华大学第一附属医院神经内科，100016。E-mail：fangliu@163.com

作者简介: 盛灿（1989-），女，山东济宁人，住院医师。E-mail：canyeweiwu2013@163.com

引用本文:

盛灿1，刘芳1，韩璎2. 临床前期阿尔茨海默病的功能MRI研究进展[J]. 中国临床医学影像杂志, 2018, 29(5): 359-362.
SHENG Can1, LIU Fang1, HAN Ying2. Progress of research on preclinical Alzheimer’s disease based on functional MRI. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(5): 359-362.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2018/V29/I5/359

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