Abstract：Objective: Using HR-MRI to explore the characteristics of arterial remodeling(including topical and general) in patients with symptomatic basilar atherosclerosis. Methods: Patients with symptomatic basilar atherosclerosis who were included in HR-MRI were divided into two groups according to whether there was infarction in the blood supply area of basilar artery (BA). 3D-VIAST T1WI imaging was used to measure and compare the plaque and wall characteristics of the patients, including plaque burden, plaque area, perivascular area, topical remodeling type and plaque enhancement degree, etc. Patients with plaque but without infarction were normal controls. The BA area and BA diameter were compared among the three groups to observe the difference of BA general remodeling. Results: There were 12 patients in the BA infarction group(plaque number: 19), 15 patients without BA infarction(plaque number: 18) and 17 patients in the normal group; positive remodeling accounted for a large proportion(63%) in the BA infarction group, and the stenosis rate was greater than that of the BA non-infarction group(P=0.029), and there was no difference in the degree of plaque enhancement among the groups; According to the topical remodeling group, the plaque area and plaque burden of the positive remodeling group were larger than those of the non-positive remodeling group(P<0.05). The area and diameter of BA in symptomatic BA plaque groups were larger than those in control group(P<0.05), but there was no difference between the two indicators in the symptomatic BA plaque groups. Conclusion: In symptomatic infarct group, positive remodeling was the main local remodeling of BA plaque, and there was general expansion remodeling in BA of symptomatic BA atherosclerosis.
严雪娇，汤 敏，张东升，张小玲，高 洁. 症状性基底动脉粥样硬化患者动脉重塑的HR-MRI研究[J]. 中国临床医学影像杂志, 2020, 31(5): 310-315.
YAN Xue-jiao, TANG Min, ZHANG Dong-sheng, ZHANG Xiao-ling, GAO Jie. HR-MRI study of arterial remodeling in patients with symptomatic basilar atherosclerosis. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(5): 310-315.
[1]de Havenon A, Mossa-Basha M, Shah L, et al. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease[J]. Neuroradiology, 2017, 59(12): 1193-1202.
[2]Wang Y, Zhao X, Liu L, et al. Prevalence and Outcomes of Symptomatic Intracranial Large Artery Stenoses and Occlusions in China[J]. Stroke, 2014, 45(3): 663-669.
[3]Feng C, Hua T, Xu Y, et al. Arterial remodeling of basilar atherosclerosis in isolated pontine infarction[J]. Neurol Sci, 2015, 36(4): 547-551.
[4]Glagov S, Weisenberg E, Zarins CK, et al. Compensatory enlargement of human atherosclerotic coronary arteries[J]. New Engl J Med, 1987, 316(22): 1371-1375.
[5]Rodriguez-Granillo GA. Coronary artery remodelling is related to plaque composition[J]. Heart, 2005, 92(3): 388-391.
[6]Birnbaum Y, Fishbein MC, Luo H, et al. Regional Remodeling of Atherosclerotic Arteries: A Major Determinant of Clinical Manifestations of Disease[J]. JACC, 1997, 30(5): 1149-1164.
[7]Ma N, Jiang WJ, Lou X, et al. Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study[J]. Neurology, 2010, 75(3): 253-258.
[8]李焰生. 中国后循环缺血的专家共识[J]. 中华内科杂志，2006，45（9）：786-787.
[9]Zhu X, Liu L, He X, et al. Wall thickening pattern in atherosclerotic basilar artery stenosis[J]. Neurol Sci, 2016, 37(2): 269-276.
[10]Qiao Y, Anwar Z, Intrapiromkul J, et al. Patterns and Implications of Intracranial Arterial Remodeling in Stroke Patients[J]. Stroke, 2016, 47(2): 434-440.
[11]Lee HN, Ryu CW, Yun SJ. Vessel-Wall Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis[J]. Front Neurol, 2018, 9(1032): 1-13.
[12]Chung GH, Kwak HS, Hwang SB, et al. High resolution MR imaging in patients with symptomatic middle cerebral artery stenosis[J]. Eur J Radiol, 2012, 81(12): 4069-4074.
[13]Pasterkamp G, Schoneveld AH, van der Wal AC, et al. Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox[J]. JACC, 1998, 32(3): 655-662.
[14]Celletti FL, Waugh JM, Amabile PG, et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression[J]. Nat Med, 2001, 7(4): 425-429.
[15]Calcagno C, Cornily JC, Hyafil F, et al. Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET[J]. Arterioscler Thromb Vasc Biol, 2008, 28(7): 1311-1317.
[16]Huang J, Jiao S, Zhao X, et al. Characteristics of patients with enhancing intracranial atherosclerosis and association between plaque enhancement and recent cerebrovascular ischemic events: a high-resolution magnetic resonance imaging study[J]. Acta Radiol, 2019, 60(10): 1301-1307.
[17]Gupta A, Baradaran H, Al-Dasuqi K, et al. Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis[J]. J Am Heart Assoc, 2016, 5(8): 1-14.
[18]Wu W, Guan Y, Xu K, et al. Plasma Homocysteine Levels Predict the Risk of Acute Cerebral Infarction in Patients with Carotid Artery Lesions[J]. Mol Neurobiol, 2016, 53(4): 2510-2517.
[19]Lu SS, Xie J, Su CQ, et al. Plasma homocysteine levels and intracranial plaque characteristics: association and clinical relevance in ischemic stroke[J]. BMC Neurol, 2018, 18(1): 200-207.
[20]Lee WJ, Choi HS, Jang J, et al. Non-stenotic intracranial arteries have atherosclerotic changes in acute ischemic stroke patients: a 3T MRI study[J]. Neuroradiology, 2015, 57(10): 1007-1013.
[21]Tanaka M, Sakaguchi M, Miwa K, et al. Basilar artery diameter is an independent predictor of incident cardiovascular events[J]. Arterioscler Thromb Vasc Biol, 2013, 33(9): 2240-2244.
2020, Vol. 31 
