2型糖尿病合并高血压对脑结构联合损伤效应的VBM研究

doi:10.12117/jccmi.2019.11.002

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摘要目的：探讨2型糖尿病（T2DM）合并高血压对脑结构及认知功能是否存在联合损伤效应。方法：对17例T2DM合并高血压患者及17例人口学资料相匹配的单纯T2DM行VBM研究及神经心理学量表测试，观察组间灰质体积改变的脑区及神经心理学量表差异，并以组间差异脑区为ROI与神经心理学量表行相关性分析。以P<0.05作为统计学差异的检验水准。结果：相对于单纯T2DM患者，T2DM+高血压患者右侧颞极区（颞上回、颞中回）、梭状回灰质体积减少，并且T2DM+高血压患者颞极区灰质体积与连线测试A（TMT-A）负相关。结论：T2DM合并高血压对脑结构及认知功能存在联合损伤效应，损伤区域主要位于右侧颞极区（颞上回、颞中回）、梭状回，合并高血压的T2DM患者发生MCI概率可能更高。

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	张东升
	严雪娇
	张小玲
	折霞
	汤敏
	高洁

关键词 ：糖尿病, 2型, 高血压, 脑损伤, 磁共振成像

Abstract：Objective: To explore the combined damage of type 2 diabetes(T2DM) and hypertension(HTN) on the cerebral gray matter and cognitive function. Methods: Seventeen diabetic participants with hypertension(T2DM+HTN) and 17 demographic matched diabetic participants without hypertension(T2DM) were enrolled and accepted voxel-based morphometry analysis and neuropsychological assessment. Demographic parameters, gray matter volumes and neuropsychological scores were compared between the two groups. Then the regions which showed significantly difference were selected as regions of interests(ROI) for the correlation analysis between the volume of gray matter and neuropsychological scores. P<0.05 was considered as statistically significant. Result: There was no significant difference of demographic parameters between the two groups. Compared with T2DM, T2DM+HTN had decreased gray matter volumes in the temporopolar area(superior and middle temporal gyrus) and fusiform gyrus, which were both negatively correlated with TMT-A. Conclusion: T2DM and HTN have combined damage on the brain structure and cognitive function, which might mainly affected the temporopolar area(superior and middle temporal gyrus) and fusiform gyrus and have a higher probability of developing MCI.

Key words： Diabetes mellitus, type 2 Hypertension Brain injuries Magnetic resonance imaging

收稿日期: 2018-12-17

PACS:	Ｒ587.1
	Ｒ743.2
	R445.2

基金资助:陕西省重点项目（基金编号：2018ZDXM-SF-038）；陕西省社会发展科技攻关项目（基金编号：2019SF-131）。

通讯作者: 高洁，陕西省人民医院MRI室，710068。E-mail：gaojie8661@163.com

作者简介: 张东升（1985-），男，甘肃庆阳人，主治医师。E-mail：yunyun122424@126.com

引用本文:

张东升，严雪娇，张小玲，折霞，汤敏，高洁. 2型糖尿病合并高血压对脑结构联合损伤效应的VBM研究[J]. 中国临床医学影像杂志, 2019, 30(11): 765-768.
ZHANG Dong-sheng, YAN Xue-jiao, ZHANG Xiao-ling, ZHE Xia, TANG Min, GAO Jie. Evaluating of voxel-based morphometry on combined damage of type 2 diabetes and hypertension. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(11): 765-768.

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http://www.jccmi.com.cn/CN/10.12117/jccmi.2019.11.002 或 http://www.jccmi.com.cn/CN/Y2019/V30/I11/765

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