1. Kangning Hospital, Mental Health Center, Shenzhen Guangdong 518020, China;
2. Medical College of Shenzhen University, Shenzhen Guangdong 518062, China;
3. Department of Imaging Diagnose, Nanshan Hospital of Shenzhen, Shenzhen Guangdong 518052, China;
4. Diagnostic Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Abstract：Objective: To evaluate the diagnostic value of CT and MR in the diagnosis of primary nasal sinus mucosal malignant melanoma. Materials and Methods: The images, pathology and clinical data of 11 cases of primary nasal sinus mucosal malignant melanoma confirmed by biopsy or pathology were retrospectively analyzed. Eleven patients underwent CT plain scan, and 5 underwent CT contrast enhancement. Three of them underwent through both MR scan and enhanced scan. The study examined the CT and MRI findings in the following aspects: the lesion location, size, border, the relationship with the surrounding tissue, and the lymph nodes. Results: In 3 cases, the tumor was located in the nasal cavity, 6 cases in both the sinus and the nasal cavity, and 2 cases in the sinus. The CT findings showed that all the tumors were irregularly shaped, with soft tissue density, but without calcification or cystic degeneration. Severe enhancement was observed in 2 cases, moderate enhancement in 3 cases. Among the 3 cases that underwent MR examination, 1 case was hyperintense on T1WI, and hypointense on T2WI. The other 2 cases were isointense on T1WI, T2WI. The mass showed mild enhancement. All the tumors invaded the surrounding bone tissue. Immunohistochemistry showed that the tumor cells were positive for HMB-45, S-100 and Vimentin. Conclusion: Primary nasal sinus mucosal malignant melanoma is not specifically manifested on CT imaging. But typical malignant melanoma has typical manifestation on MR. CT combined with MR can accurately show the location of the tumor, and the invasive relationship between the lesion and the surrounding tissues.
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