Abstract：Objective: To explore the diagnostic value of 3.0T MRI on fetal abnormalities of cavum septum pellucidum. Methods: Two hundred and sixty-one pregnant women, aged from 18 to 41 years(average 28 years) with gestation weeks from 21 to 40 weeks(average 26 weeks), and with fetal abnormalities ultrasound of cavum septum pellucidum, were studied with a 3.0T MRI unit within seventy-two hours after ultrasound studies. The imaging protocol included half-flourier acquisition single-shot turb spin-echo and true fast imaging and fast low angle shot and DWI sequences in the axial, frontal and sagittal planes relative to the fetal brain. MRI findings were compared with prenatal US. Results: Of the 261 pregnant women, 264 live fetuses were found(twins 3 cases), 50 cases with septum pellucidum absence and corpus callosum hypoplasia, 110 cases with small cavum septum pellucidum, 12 cases with enlarged cavum septum pellucidum, 7 cases with isolated absence of cavum septum pellucidum, 3 cases with septum pellucidum and without cavum, 2 cases with septum pellucidum partial absence and normal corpus callosum, 2 cases with septum pellucidum absence and holoprosencephaly, and 78 cases with negative results. Ultrasound diagnosis of 60 cases were completed, 44 cases were corrected and by MRI results and 160 cases etc. diagnosis were the same as ultrasound. Conclusion: Prenatal MRI is effective in the assessment of fetal abnormalities of cavum septum pellucidum; it can yield information additional to that obtained with US, especially complicated with cerebral hemorrhage, midline lipoma or midline cyst. And it further corrects US diagnosis.
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