胎儿透明隔间腔异常的MRI产前诊断价值

doi:10.12117/jccmi.2019.07.007

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摘要目的：分析探讨胎儿透明隔腔及合并神经系统异常的产前MRI影像特征及诊断价值。方法：回顾性搜集2015年6月—2018年6月2 361例于四川省妇幼保健院就诊孕妇的临床资料，均行MRI及超声检查，总结其相关临床及影像学资料。结果：胎儿头颅MRI检查提示透明隔腔及合并神经系统异常332例，超声提示胎儿透明隔异常212例。孕妇年龄17~41岁，孕周21~39周+3。MRI检查结果提示单纯透明隔腔异常胎儿共221例，包括完全缺如8例、部分缺如7例、增宽92例、纤细114例。透明隔异常合并其他神经系统异常胎儿共111例，包括胼胝体完全缺如68例、胼胝体部分缺如16例、视-隔发育不良3例、前脑无裂畸形9例（包括无脑叶型2例，半脑叶型2例，脑叶型5例）、脑裂畸形3例、脑损伤4例、脑积水4例、多发畸形2例、孔洞脑2例。结论：胎儿透明隔及合并神经系统异常的MRI表现具有特征性，MRI可检出超声不能发现的异常，较超声有明显优势，可更加精准诊断，提高产前诊断的准确率，减少重大缺陷儿的出生。

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	陶元萍
	康敏
	曹倩
	陈霞
	陈瑞
	王齐艳

关键词 ：透明隔, 胎儿疾病, 磁共振成像

Abstract：Objective: To analyze and discuss the prenatal MRI features and diagnostic value of the fetal cavum septum pellucidum and its associated neurological abnormalities. Methods: From June 2015 to June 2018, 2 361 cases of fetuses from Sichuan Provincial Women and Children Hospital were included in our research. All the fetuses received 1.5T MR and ultrasonography(US) examination. We gathered the clinical information and analyzed the MR imaging. Results: 332 fetuses detected by MRI examination of fetal head revealed cavum septum pellucidum and associated nervous system abnormalities. In these cases, ultrasonography indicated 212 cases of cavum septum pellucidum. The age of the maternal and gestational week was 17~41 years old and 21~39W+3, respectively. MRI presented 221 cases of fetuses with pure cavum septum pellucidum abnormality, including 8 of complete absence of cavum septum pellucidum, 7 cases of partial absence, 92 cases of broadening, and 114 cases of narrowing. One hundred and eleven cases of fetus with cavum septum pellucidum anomaly combined with other neurological abnormalities, including 68 cases of corpus callosum complete absence, 16 cases of corpus callosum partial absence, 3 cases of visual-septal dysplasia, 9 cases of holoprosencephaly（HPE, including 2 alobar HPE, 2 semilobular HPE and 5 lobar HPE), 3 cases of Schizencephaly, 4 cases of brain injury, 4 cases of hydrocephalus, 2 cases of multiple malformations and 2 cases of porencephaly. Conclusions: MRI findings and presentations of fetal cavum septum pellucidum and combined neurological abnormality were characteristic. MRI has obvious advantages over US, which can manifest fetus central nervous system abnormalities not detected by US. MRI can diagnose more accurately and improve the accuracy of prenatal diagnosis of fetal central nervous system abnormalities so that reduce the birth rate of children with major defects.

Key words： Septum pellucidum Fetal diseases Magnetic resonance imaging

收稿日期: 2019-02-13

PACS:	Ｒ714.53
	Ｒ445.2

通讯作者: 康敏，四川省妇幼保健院放射科，610041。E-mail：1073297610@qq.com

作者简介: 陶元萍（1987-），女，四川内江人，初级医师。E-mail：261012550@qq.com

引用本文:

陶元萍，康敏，曹倩，陈霞，陈瑞，王齐艳. 胎儿透明隔间腔异常的MRI产前诊断价值[J]. 中国临床医学影像杂志, 2019, 30(7): 487-494.
TAO Yuan-ping, KANG Min, CAO Qian, CHEN Xia, CHEN Rui, WANG Qi-yan. The value of prenatal diagnosis for abnormality of fetal cavum septum pellucidum by MRI. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(7): 487-494.

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http://www.jccmi.com.cn/CN/10.12117/jccmi.2019.07.007 或 http://www.jccmi.com.cn/CN/Y2019/V30/I7/487

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