Abstract：Objective: To investigate the value of MRI in the prenatal diagnosis of abnormal fetal spine and spinal cord. Methods: Eighty-nine cases of single fetus, with suspected spine or spinal cord. Abnormal development detected during routine ultrasound screening, were rescanned by MRI to compare the diagnosis. All fetuses included are single fetuses at an average of 28 weeks of gestation(range 22~39) and the mean maternal age was 27 years(range 21~41). The MRI protocol was as follows: T2WI included half-flourier acquisition single-shot turb spin-echo(HASTE) and true fast imaging with steady state precession (True FISP), and T1WI used fast low angle shot in the axial(FLASH). Partial fetal underwent scanning with 3D-SWI. The pregnancy outcome was examined externally and by postnatal ultrasonography or MRI. Results: Eighty-nine fetuses contains 26 cases of vertebral dysplasia, 24 cases of spinal cord dysplasia, and 35 cases of vertebral complex malformation. The diagnostic accuracy of prenatal MRI was 100%(26/26), 91.7%(22/24), 85.7%(30/35), respectively, while the diagnostic accuracy of prenatal US was 88.5%(23/26), 45.8%(11/24), 45.7%(16/35) respectively. MRI showed higher diagnostic accuracy rate than US(P<0.05) in vertebral dysplasia while no significant difference in spinal cord dysplasia or vertebral complex malformation(P>0.05). Conclusion: Prenatal MRI is effective in the assessment of fetal spine and spinal cord dysplasia, especially in dysplasia of spinal cord. Prenatal MRI, especially with SWI sequence, has a promising application prospect in prenatal diagnosis of fetuses.
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