Abstract：Objective: To evaluate the value of dynamic contrast-enhanced MRI(DCE-MRI) with hemorrheology in the detection of femoral perfusion in the early stage of steroid-induced avascular necrosis of femoral head(AvNFH) model. Methods: Twenty-five rabbits were examined by non-enhanced, DCE-MRI with the same method before treatment and in the second week, fourth week, sixth week and eighth week after steroid treatment. Venous blood was obtained for hemorrheology in the fourth week, eighth week. After rabbits were killed, paraffin section and HE stained specimen of all the femoral heads were made for pathological investigation. Results: ①The steepest slope(SS) of time-signal intensity curve gradually declined with time in the early stage and intensity of perfusion decreased gradually(P<0.01). Correspondingly, the number of empty lacuna increased gradually(P<0.01). ②Compared with normal group, the indexes of experimental group including whole blood(high and low slice) viscosity, viscosity of plasma and packed cell volume elevated, but only the increase of whole blood(low slice) viscosity, packed cell volume were significant(P<0.05). ③The parameter SS of DCE-MRI correlated negatively with whole blood(low slice)(r=-0.65, P<0.05). Conclusion: DCE-MRI can evaluate the state of blood perfusion of femoral head and is valuable for early diagnosis.
2007, Vol. 18 
