Correlative study between peritumoral edema on MRI and P53 protein in supratentorial astrocytic gliomas
ZHOU Dong-hai1, HE Ning2, HUANG Jin1, ZHANG Jing2, ZHAO Zhi-wen1, LI Bing-cui1, LI Gang2, WEI Chun-ping2
1. Department of Radiology, Center Hospital, Kelamayi City, Kelamayi Xinjiang 834000, China; 2. Department of Radiology, Second Hospital, Lanzhou University, Lanzhou 730030, China
Abstract：Objective: To analyse the peritumoral edema of supratentorial astrocytic gliomas on MRI, to investigate the correlation between the MRI scores of peritumoral edema degree and P53 protein. To reveal the molecular biological foundation of MRI of peritumoral edema in supratentorial astrocytic gliomas. Methods: We analyzed MR features of 42 cases peritumoral edema in the supratentorial astrocytic gliomas verified by surgery and pathology, including 5 grade Ⅰ, 8 grade Ⅱ, 10 grade Ⅲ and 19 grade Ⅳ tumors. All the cases were divided into 4 groups according to the scores of peritumoral edema. Histopathological slides underwent P53 protein immunohistochemical staining. The expressions of P53 protein were analyzed and compared with their scores of peritumoral edema. The data were correlatively studied. Results: In 42 cases, the positive expression rate of P53 protein was 10% to 85% with an average of 48.35%±23.44%. The positive expression rate of P53 protein increased with the increasing of peritumoral edema scores(P<0.05). Conclusion: The peritumoral edema on MRI in supratentorial astrocytic gliomas can reflect the positive expression rate of P53 protein. MRI may prove to be a valuable means in estimating the expression of P53 protein in supratentorial astrocytic gliomas quickly and noninvasively, and further predicting the molecular biological behavior of supratentorial astrocytic gliomas and judging the prognosis.
2007, Vol. 18 
