Contrast-enhanced MR imaging of nude mice grafted with hepatocellular carcinoma using blood pool contrast agent Gd-DTPA-streptavidin
LIU Xian1, YE Jing2, XU Yi-kai2, LIU Bo1
1.Department of Radiology, Guangdong Traditional Chinese Medicine Hospital, Guangzhou 510120, China;2.Medical Imaging Center, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China
Abstract：Objective: To evaluate MR enhanced characteristics of tumor using blood pool MR contrast agent Gd-DTPA-streptavidin. Methods: Measure R1 relaxation rate of Gd-DTPA-SA after preparation. Fourteen nude mice bearing human hepatocelluar carcinoma were injected with Gd-DTPA-SA. MR scan was performed before and at 30min, 60min, 3h, 6h, 12h, and 24h after injection of MR contrast agents. Signal intensity of tumor core, rim and muscle on nonenhanced and enhanced images were measured to make enhancement time course. Contrast-to-noise of tumor was also calculated. Results: R1 relaxation rate of Gd-DTPA-SA was 18.0l?蛐(mmol·s). After injection of Gd-DTPA-SA, the tumor demonstrated increasing signal with a stepwise pattern. At 6h after injection, enhanced ratio and CNR of tumor rim were largest, which had significant difference from other times. The signal intensity of tumor core showed the highest value at 12h after injection. But the muscle did not enhance significantly. Conclusion: Blood pool MR contrast agent Gd-DTPA-SA have potential value for evaluating microvessel permeability and blood volume of tumor.
2007, Vol. 18 
