Diagnosis of multimode magnetic resonance imaging in MELAS
HUANG Chun-yuan1, YANG Zhi-yun2, XU Zhao-xuan1, HOU Yu1, CHEN Su-yun1, WU Qian-hong1, ZHAO Zhi-qing1, LUO Di-lin1
1. Department of Radiology, Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University, Shenzhen Guangdong 518104, China; 2. Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Abstract：Objective: To investigate multimode magnetic resonance finding imaging in the patients with MELAS type of mitochondrial encephalomyopathy. Methods: MRI, MRA, DWI and MRS manifestations of 11 cases with MELAS were retrospectively analyzed. Results: In 11 cases, the lesions were mainly distributed in the cortical zones of occipital and parietal lobe, hippocampus, parahippocampal gyrus were involved in 5 cases, and basal ganglia involvement in 5 cases too. The distribution of the lesions was multiple, wandering and variable, and the location was not corresponding with the vascular supply territories． Four cases presented cerebellum and(or) cerebellar atrophy. Seven cases showed no enhancement after contrast scanning. In 1 of the 7 cases with MRA, there were increased arterial branches of the lesions zone, other 6 cases were normal. In 5 cases, the lesions showed hyperintensity and(or) slight hyperintensity on DWI, slight hyperintensity(2 cases) or hypointensity(2 cases) or mix-intensity(1 case) on ADC images. The focal lesions and relatively normal areas showed increasing Lac peak on 1H-MRS. The quantitative analysis manifested that the value of Lac and Lac/Cr were obviously increased(P<0.001) in the focal lesions than the normal areas. Conclusion: Multimode magnetic resonance image is relatively specific to MELAS and can make diagnosing MELAS with comprehensive analysis.
2014, Vol. 25 
