Application of arterial spin labeling and intra-voxel incoherent motion imaging in preoperative glioma
ZHANG Yu-qin1, XU Hai-dong1, DONG Hai-bo1, WANG Bo1, XU Tian-yong2
1.Department of Radiology, Ningbo Medical Center Lihuili Hospital, Ningbo Zhejiang 315041, China;2.General Electric(China) Medical Group, Shanghai 201203, China
Abstract：Objective: To investigate the three-dimensional arterial spin labeling(ASL) and intra-voxel incoherent motion(IVIM) value in preoperative grading of cerebral glioma. Materials and Methods: Forty-five patients with glioma proved by pathology(26 cases of high grade glioma and 19 cases of low grade glioma) underwent 3D-ASL and IVIM-DWI examination. Cerebral blood flow(CBF) in the most obvious perfusion area of the solid part of tumor and also in the contralateral normal area were measured using cerebral blood flow map. By fitting double exponential model, got the fast ADC map. On 3D-ASL, the ADC value in the solid part of the tumor and also in the contralateral normal area of the same section were measured. Results: CBF ratios of the lesion and contralateral normal area in high and low grade gliomas were 3.11±1.45 and 0.86±0.28 respectively, the fast ADC value were 1.88±0.51 and 0.96±0.31 respectively. There was significant differences between the two groups(P<0.05). Conclusion: 3D-ASL and IVIM techniques are safe and noninvasive methods to extract information of perfusion in gliomas and thus can be used as methods for determining the grade of gliomas before operation.
2014, Vol. 25 
